Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

Rodríguez-Fernández, Blanca; Sánchez Benavides, Gonzalo; Genius, Patricia; Minguillón, Carolina; Fauria, Karine; De Vivo, Immaculata; Navarro i Cuartiellas, Arcadi, 1969-; Molinuevo, José Luis; Gispert López, Juan Domingo; Sala Vila, Aleix; Vilor Tejedor, Natàlia, 1988-; Crous-Bou, Marta; ALFA Study

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dc.contributor.author	Rodríguez-Fernández, Blanca
dc.contributor.author	Sánchez Benavides, Gonzalo
dc.contributor.author	Genius, Patricia
dc.contributor.author	Minguillón, Carolina
dc.contributor.author	Fauria, Karine
dc.contributor.author	De Vivo, Immaculata
dc.contributor.author	Navarro i Cuartiellas, Arcadi, 1969-
dc.contributor.author	Molinuevo, José Luis
dc.contributor.author	Gispert López, Juan Domingo
dc.contributor.author	Sala Vila, Aleix
dc.contributor.author	Vilor Tejedor, Natàlia, 1988-
dc.contributor.author	Crous-Bou, Marta
dc.contributor.author	ALFA Study
dc.date.accessioned	2024-07-16T06:38:24Z
dc.date.available	2024-07-16T06:38:24Z
dc.date.issued	2024
dc.identifier.citation	Rodríguez-Fernández B, Sánchez-Benavides G, Genius P, Minguillon C, Fauria K, De Vivo I, et al. Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease. Neurobiol Aging. 2024 Jun 1;141:140-50. DOI: 10.1016/j.neurobiolaging.2024.05.015
dc.identifier.issn	0197-4580
dc.identifier.uri	http://hdl.handle.net/10230/60762
dc.description.abstract	Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.
dc.description.sponsorship	The project leading to these results has received funding from the Alzheimer’s Association (Grant AARG-19–618265). This project has received funding from Instituto de Salud Carlos III (PI19/00119). Additional support has been received from 'la Caixa' Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004, the Alzheimer’s Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17–519007), the Health Department of the Catalan Government (Health Research and Innovation Strategic Plan (PERIS) 2016–2020 grant# SLT002/16/00201), and the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2017-SGR-892. All CRG authors acknowledge the support of the Spanish Ministry of Science, Innovation, and Universities to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Programme / Generalitat de Catalunya. JDG is supported by the Spanish Ministry of Science and Innovation (RYC-2013–13054). GSB has received funding from the Spanish Ministry of Science and Innovation, Spanish Research Agency (PID2020–119556RA-I00). JDG is supported by the Spanish Ministry of Science and Innovation (RYC-2013–13054). NV-T is funded by the Juan de la Cierva Incorporación Programme (IJC2020–043216-I), Ministry of Science and Innovation– Spanish State Research Agency.
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartof	Neurobiol Aging. 2024 Jun 1;141:140-50
dc.rights	© 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title	Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.1016/j.neurobiolaging.2024.05.015
dc.subject.keyword	Alzheimer’s disease
dc.subject.keyword	Biological aging
dc.subject.keyword	Cognitive performance
dc.subject.keyword	Sex differences
dc.subject.keyword	Telomere length
dc.relation.projectID	info:eu-repo/grantAgreement/ES/2PE/PID2020–119556RA-I00
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/publishedVersion