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TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth

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dc.contributor.author Molnar, Cristina
dc.contributor.author Heinen, Jan Peter
dc.contributor.author Reina, José
dc.contributor.author Llamazares, Salud
dc.contributor.author Palumbo, Emilio
dc.contributor.author Pollarolo, Giulia
dc.contributor.author González, Cayetano
dc.date.accessioned 2024-07-10T06:20:37Z
dc.date.available 2024-07-10T06:20:37Z
dc.date.issued 2024
dc.identifier.citation Molnar C, Heinen JP, Reina J, Llamazares S, Palumbo E, Pollarolo G, et al. TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth. EMBO Rep. 2024 May 15. DOI: 10.1038/s44319-024-00154-1
dc.identifier.issn 1469-221X
dc.identifier.uri http://hdl.handle.net/10230/60716
dc.description Data de publicació electrònica: 15-05-2024
dc.description.abstract Expression of the Drosophila cancer-germline (CG), X-linked, head-to-head gene pair TrxT and dhd is normally germline-specific but becomes upregulated in brain tumours caused by mutation in l(3)mbt. Here, we show that TrxT and dhd play a major synergistic role in the emergence of l(3)mbt tumour-linked transcriptomic signatures and tumour development, which is remarkable, taking into account that these two genes are never expressed together under normal conditions. We also show that TrxT, but not dhd, is crucial for the growth of l(3)mbt allografts, hence suggesting that the initial stages of tumour development and long-term tumour growth may depend on different molecular pathways. In humans, head-to-head inverted gene pairs are abundant among CG genes that map to the X chromosome. Our results identify a first example of an X-linked, head-to-head CG gene pair in Drosophila, underpinning the potential of such CG genes, dispensable for normal development and homoeostasis of somatic tissue, as targets to curtail malignant growth with minimal impact on overall health.
dc.description.sponsorship The authors are very grateful to the Functional Genomics Facility of IRB Barcelona for their technical assistance; Jan Larsson and the Bloomington Stock Center for fly strains; the Developmental Studies for Hybridoma Bank for antibodies; and to all members of our laboratory for very helpful discussions. This research was supported by grants PGC2018-097372-B-100 funded by the Ministry of Science, Innovation, and Universities-Spanish State Research Agency and ERC AdG 2011 294603.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher EMBO Press
dc.relation.ispartof EMBO Rep. 2024 May 15
dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associat
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s44319-024-00154-1
dc.subject.keyword Cancer-Germline Genes
dc.subject.keyword Cancer-Testis Genes
dc.subject.keyword Malignant Growth
dc.subject.keyword Tumours
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/294603
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-097372-B-100
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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