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Navigating the semantic space: unraveling the structure of meaning in psychosis using different computational language models

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dc.contributor.author He, Rui
dc.contributor.author Palominos Flores, Claudio Antonio
dc.contributor.author Zhang, Han
dc.contributor.author Alonso-Sánchez, Maria Francisca
dc.contributor.author Palaniyappan, Lena
dc.contributor.author Hinzen, Wolfram
dc.date.accessioned 2024-05-21T09:10:23Z
dc.date.available 2024-05-21T09:10:23Z
dc.date.issued 2024
dc.identifier.citation He R, Palominos C, Zhang H, Alonso-Sánchez MF, Palaniyappan L, Hinzen W. Navigating the semantic space: unraveling the structure of meaning in psychosis using different computational language models. Psychiatry research. 2024 Mar;333:115752. DOI: 10.1016/j.psychres.2024.115752
dc.identifier.issn 0165-1781
dc.identifier.uri http://hdl.handle.net/10230/60203
dc.description Includes supplementary materials for the online appendix.
dc.description.abstract Speech in psychosis has long been ascribed as involving `loosening of associations'. We pursued the aim to elucidate its underlying cognitive mechanisms by analysing picture descriptions from 94 subjects (29 healthy controls, 18 participants at clinical high risk, 29 with first-episode psychosis, and 18 with chronic schizophrenia), using five language models with different computational architectures: FastText, which represents meaning non-contextually/statically; BERT, which represents contextual meaning sensitive to grammar and context; Infersent and SBERT, which provide sentential representations; and CLIP, which evaluates speech relative to a visual stimulus. These models were used to quantify semantic distances crossed between successive tokens/sentences, and semantic perplexity indicating unexpectedness in continuations. Results showed that, among patients, semantic similarity increased when measured with FastText, Infersent, and SBERT, while it decreased with CLIP and BERT. Higher perplexity was observed in first-episode psychosis. Static semantic measures were associated with clinically measured impoverishment of thought and referential semantic measures with disorganization. These patterns indicate a shrinking conceptual semantic space as represented by static language models, which co-occurs with a widening in the referential semantic space as represented by contextual models. This duality underlines the need to separate these two forms of meaning for understanding mechanisms involved in semantic change in psychosis.
dc.description.sponsorship This research was supported by the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Investigación (AEI) (grant PID2019-105241GB-I00/AEI/10.13039/501100011033 to WH), the grant TRUSTING, HORIZON-HLTH-2022-STAYHLTH-01, grant nr. 101080251-2 (to WH), China Scholarship Council (grant 202108390062 to RH), the Department of Science and Technology of Guangdong Province (grant 112175605105 to WH and RH), and the National Agency for Research and Development (ANID), Scholarship Program, Becas Chile 2019, Postdoctoral Fellow 74200048 (MA) (to MFAS). The data acquisition for this study was funded by CIHR Foundation Grant (FDN 154296) to LP and was supported by the Canada First Excellence Research Fund to BrainSCAN, Western University (Imaging Core); Innovation fund for Academic Medical Organization of Southwest Ontario; Bucke Family Fund, The Chrysalis Foundation and The Arcangelo Rea Family Foundation (London, Ontario). Compute Canada Resources (Application no. 1530) were used in the storage and analysis of imaging data. LP acknowledges research support from the Canada First Research Excellence Fund, awarded to the Healthy Brains, Healthy Lives initiative at McGill University (New Investigator Supplement); Monique H. Bourgeois Chair in Developmental Disorders and Graham Boeckh Foundation (Douglas Research Centre, McGill University) and a salary award from the Fonds de recherche du Quebec-Sante' (FRQS).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Psychiatry research. 2024 Mar;333
dc.rights © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Navigating the semantic space: unraveling the structure of meaning in psychosis using different computational language models
dc.type info:eu-repo/semantics/article
dc.date.updated 2024-05-21T09:10:23Z
dc.identifier.doi http://dx.doi.org/10.1016/j.psychres.2024.115752
dc.subject.keyword Connected speech
dc.subject.keyword Incoherence
dc.subject.keyword Semantic similarity
dc.subject.keyword Semantic perplexity
dc.subject.keyword Language model
dc.subject.keyword Loosening of associations
dc.subject.keyword Schizophrenia
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/PID2019-105241GB-I00
dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101080251
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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