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Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty

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dc.contributor.author Pusceddu, Claudio
dc.contributor.author Marsico, Salvatore
dc.contributor.author Derudas, Daniele
dc.contributor.author Ballicu, Nicola
dc.contributor.author Melis, Luca
dc.contributor.author Zedda, Stefano
dc.contributor.author De Felice, Carlo
dc.contributor.author Calabrese, Alessandro
dc.contributor.author De Francesco, Davide
dc.contributor.author Venturini, Massimo
dc.contributor.author Santucci, Domiziana
dc.contributor.author Faiella, Eliodoro
dc.date.accessioned 2024-05-21T06:24:22Z
dc.date.available 2024-05-21T06:24:22Z
dc.date.issued 2023
dc.identifier.citation Pusceddu C, Marsico S, Derudas D, Ballicu N, Melis L, Zedda S, et al. Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty. J Clin Med. 2023 Jun 21;12(13):4178. DOI: 10.3390/jcm12134178
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/60197
dc.description.abstract (1) Background: to retrospectively evaluate safety and efficacy of combined microwave ablation (MWA) and bilateral expandable titanium SpineJack (SJ) implants followed by vertebroplasty (VP) for the treatment of painful thoracolumbar pathological vertebral compression fracture. (2) Methods: from July 2017 to October 2022, twenty-eight patients (13 women and 15 men; mean age 68 ± 11 years) with a history of primary neoplasm and thirty-six painful vertebral metastases with vertebral compression fracture underwent combined MWA and bilateral expandable titanium SpineJack implants with vertebroplasty. We analyzed safety through complications rate, and efficacy through vertebral height restoration and pain decrease, evaluated using a visual analogue scale (VAS), and Functional Mobility Scale (FMS), and local tumor control. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI at 6 months after the procedure. (3) Results: Technical success rate was 100%. No procedure-related major complications or death occurred. Vertebral height restoration was observed in 22 levels (58%), with a mean anterior height restoration of 2.6 mm ± 0.6 and a mean middle height restoration of 4.4 mm ± 0.6 (p < 0.001). Mean VAS score of pain evaluation on the day before treatment was 6.3 ± 1.5 (range 4-9). At the 6-month evaluation, the median VAS score for pain was 0.4 ± 0.6 (range 0-2) with a mean reduction of 93.65% (6.8 ± 0.7 vs. 0.4 ± 0.6; p < 0.000) compared with baseline evaluation. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI was performed at 6 months after the procedure, showing no local recurrence, implant displacement, or new fractures in the treated site. (4) Conclusions: combined microwave ablation and bilateral expandable titanium SpineJack implants with vertebroplasty is a safe and effective procedure for the treatment of pathological compressive vertebral fractures. The vertebral stabilization achieved early and persistent pain relief, increasing patient mobility, improving recovery of walking capacity, and providing local tumor control.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof J Clin Med. 2023 Jun 21;12(13):4178
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm12134178
dc.subject.keyword Expandable titanium SpineJack implants
dc.subject.keyword Interventional radiology
dc.subject.keyword Microwave ablation
dc.subject.keyword Percutaneous therapies
dc.subject.keyword Spine metastases
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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