Inici
→
Recerca: tesis
→
TDX
→
Visualitza TDX per autoria

Visualitza TDX per autoria "Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut"

Ara mostrant els elements 1-20 de 1151

Pàgina següent

1)Jarid2 regulates mouse epidermal stem cell activation and differentiation ; 2)Tumor heterogeneity and metastasis-initiation in human squamous cell carcinoma

Mejetta, Stefania (Universitat Pompeu Fabra, 2014-10-31)

Jarid2 is required for the genomic recruitment of the polycomb repressive complex-2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains largely uncharacterized. In ...
A 3D culture system to study gene regulation in breast cancer cells

Ramírez Cuéllar, Angélica Julieta (2022-05-16)

In this Thesis we report the successful growth of hormone responsive T47D cells as 3D spheroids in Matrigel mimicking the ECM. A detailed characterization by using a genome-wide approach of the main physical and biochemical ...
A Bioinformatics approach to the study of comorbidity : Insight into mental disorders

Gutiérrez-Sacristán, Alba (Universitat Pompeu Fabra, 2018-12-17)

Estudios clínicos y epidemiológicos muestran que la comorbilidad, la coexistencia de varias enfermedades en un mismo paciente, tiene un gran impacto en la evolución de su estado de salud. Por lo tanto, el análisis de ...
A Comprehensive multiomics approach towards understanding obsessive-compulsive disorder

Domènech Salgado, Laura (Universitat Pompeu Fabra, 2019-02-18)

To date, very little progress has been made towards elucidating the genetic causes of obsessive-compulsive disorder (OCD). In this project we have performed rare variant association study (RVAS) transcriptomics and ...
A Comprehensive screening of X-linked and miRNA-driven signatures of positive selection and the role of cis-regulatory elements in the human genome

Villegas Mirón, Pablo (2021-10-22)

The evolutionary history of the human genome has been shaped by the selection of multiple elements in response to different environmental pressures. The analysis of regulatory adaptations and the particularities of sexual ...
A Computational toolkit to boost precision oncology with pharmacogenomics

Mateo Ramos, Lídia (Universitat Pompeu Fabra, 2020-01-21)

Durant la darrera dècada la seqüenciació massiva de pacients de cancer ha permés avançar de forma significativa el coneixement sobre les bases moleculars del càncer. Un cop assolit aquest primer pass, el repte que tenim ...
A dynamic Turing model of digit patterning : a Turing mechanism modulated by positional information underlies digit specification

Marcon, Luciano (Universitat Pompeu Fabra, 2015-05-27)

The specification of the vertebrate limb skeleton is a classical model to study pattern formation during development. Two different theories have been proposed to explain this process: the Turing mechanism and the Positional ...
A functional study of the conserved LSM proteins in C. elegans reveals their involvement in the stress response of metazoans

Cornes Maragliano, Eric (Universitat Pompeu Fabra, 2015-10-27)

Lsm proteins regulate RNA metabolism and are conserved in the three domains of life, typically functioning as RNA-binding complexes involved in a wide range of post-transcriptional mechanisms. Generally, their functions ...
A midzone-based ruler adjusts chromosome compaction to analphase spindle length

Neurohr, Gabriel Erich (Universitat Pompeu Fabra, 2012-06-15)

Partitioning of chromatids during mitosis requires that chromosome compaction and spindle length scale appropriately with each other. However, it is not clear whether chromosome condensation and spindle elongation are linked. ...
A molecular approach to taxol biosynthesis

Onrubia Ibáñez, Miriam (Universitat Pompeu Fabra, 2012-06-29)

Secondary metabolism in plants produces numerous compounds with wide-ranging activities, including the antineoplastic compound taxol and related taxanes. The biotechnological production of taxol has so far been based on ...
A multidimensional approach to precarious employment: measurement, association with poor mental health and prevalence in the Spanish workforce

Vives Vergara, Alejandra (Universitat Pompeu Fabra, 2011-06-09)

Objective: To study the psychometric properties and construct validity of a multidimensional instrument to measure employment precariousness; to assess the association between employment precariousness and poor mental ...
A Multivariate approach to study the genetic determinants of phenotypic traits

Garrido Martín, Diego (Universitat Pompeu Fabra, 2020-02-05)

We have developed an efficient and reproducible pipeline for the identification of genetic variants affecting splicing (splicing quantitative trait loci or sQTLs), based on an approach that captures the intrinsically ...
A new Ligand-Based approach to virtual screening, and prolifing or large chemical libraries

Gregori Puigjané, Elisabet (Universitat Pompeu Fabra, 2011-04-12)

La representació de les molècules per mitjà de descriptors moleculars és la base de moltes de les eines computacionals pel disseny de fàrmacs. Aquests mètodes computacionals es basen en l'abstracció de l'estructura química ...
A physician-in-the-loop approach by means of machine learning for the diagnosis of lymphocytosis in the clinical laboratory

Bigorra López, Laura (2022-05-16)

The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...
A Screen for novel factors involved in pluripotency and X-chromosome reactivation

Generoso, Serena Francesca (Universitat Pompeu Fabra, 2019-04-02)

X-Chromosome Reactivation (XCR) occurs in the epiblast cells of the blastocyst and in germ cells, thereby coupling XCR with pluripotency. We performed a screen in iPS cells by knocking down the expression of candidate genes ...
A Study of intrinsically disordered proteins using molecular dynamics simulations

Herrera Nieto, Pablo (Universitat Pompeu Fabra, 2020-11-30)

Over the last decades molecular dynamics simulations have been successfully applied to relevant biological problems such as protein-ligand, protein-protein binding as well as protein folding. A perfect challenge for molecular ...
A study on autocatalysis through synthetic biology. Exploration of spatiotemporal dynamics in the presence or absence of synthetic autocatalytic Hepatocyte Growth Factor signaling in mammalian cells

Bárcena Menéndez, Diego (Universitat Pompeu Fabra, 2018-05-03)

Una de las preguntas sin resolver en la biologia celular, es como las células mamíferas logran generar patrones estables como organos o seres vivos, en un entorno variable. El concepto matemático del bucle de retreoalimentación, ...
A system-level, molecular evolutionary analysis of mammalian phototransduction

Invergo, Brandon M. (Universitat Pompeu Fabra, 2014-06-19)

Phototransduction is the biochemical process by which a light stimulus is converted to a neuronal signal. The process functions through complex interactions between many proteins, which work in concert to tightly control ...
A Systems-level study of giant regulation in Drosophila melanogaster

Hoermann, Astrid (Universitat Pompeu Fabra, 2015-02-27)

Esta tesis revela la regulación transcripcional del gen gap giant (gt) en el embrión blastodermal de Drosophila por ingeniería inversa: un modelo matemático infiere los mecanismos subyacentes de datos cuantitativos de ...
A unified approach to the emergence of complex communication

Corominas Murtra, Bernat (Universitat Pompeu Fabra, 2011-10-04)

Aquesta tesi estudia l'emergència de complexitat en sistemes de comunicació naturals, prenent el llenguatge humà com a principal objecte d'estudi. Ens centrem en i) Patrons estadístics de complexitat, ii) Mecanismes ...