ListarTDX por tema "Dany a l'ADN"

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H3K4ox a new epigenetic mark : characterization of H3K4ox as a new epigenetic mark and its role in chomatin condensation

Cebrià i Costa, Joan Pau (Universitat Pompeu Fabra, 2018-06-28)

L’oxidació de la histona 3 en la lisina 4 (H3K4ox) per acció de la lysil oxidase-like 2 (LOXL2) genera una nova modificació de la H3 amb una funció desconeguda. En aquesta tesi, hem determinat tant en línies cel·lulars com ...
The Role of cyclin O in the DNA damage response

Núñez Ollé, Marc (Universitat Pompeu Fabra, 2018-01-18)

Cyclin O, a novel identified CDK1 and CDK2-binding cyclin, has been demonstrated to be required for γ-radiation induced apoptosis in a lymphoid cell line. Ɣ-radiation induces the formation of DSBs in the DNA what activate ...
Unravelling new oncogenic functions of IKKα : towards a better understanding of colorectal carcinogenesis

Colomer Montañà, Carlota (Universitat Pompeu Fabra, 2019-01-14)

Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...