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Browsing TDX by Title
Now showing items 3194-3213 of 3325
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(Universitat Pompeu Fabra, 2018-12-11)The exonuclease Xrn1 degrades messenger RNAs (mRNAs) and controls transcription. By using a model system that replicates brome mosaic virus (BMV) in yeast, here we show that Xrn1 promotes translation initiation of BMV RNA. ...
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(Universitat Pompeu Fabra, 2023-09-29)La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten o inhibeixen la ...
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(Universitat Pompeu Fabra, 2019-12-12)The Lower Rhombic Lip (LRL) is a transient neuroepithelial structure of dorsal hindbrain that gives rise to deep brainstem nuclei like the vestibular, auditory and precerebellar nuclei. In this work, we have followed the ...
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(Universitat Pompeu Fabra, 2018-06-05)The activity of the brain at rest reveals an intricate functional architecture and yet, the underlying mechanisms generating it are still not well understood. Whole-brain computational models have turned into fundamental ...
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(Universitat Pompeu Fabra, 2020-03-02)Alternative pre-mRNA splicing is a regulated step in eukaryotic gene expression in which introns are removed from the transcript and exons are joined together to form a mature mRNA. To study the effects of mutations on ...
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(Universitat Pompeu Fabra, 2024-04-03)The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the adaptations in the ...
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(Universitat Pompeu Fabra, 2020-07-22)When watching television, many people use social media to share real-time opinions and feelings. The mediated co-viewing is widely studied under the name of “second screen” or “social TV”. In Japan and China, a technology ...
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(Universitat Pompeu Fabra, 2016-05-30)This thesis has been about the use of a simulation technique, known as molecular dynamics simulations, to study biophysics in proteins that have historically been difficult to study with other methods. We have studied ...
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(Universitat Pompeu Fabra, 2020-02-17)L’estudi de la variació estructural complementa l’estudi de la variació de seqüència per revelar les complexitats de la variació fenotípica. Els gossos són l’espècie domesticada amb més variació fenotípica que existeix ...
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(Universitat Pompeu Fabra, 2023-02-28)According to estimates, over the 3.5 billion years that have elapsed since the appearance of life, the Earth has been inhabited by some 4 billion different species, of which 99.99% have already become extinct. Extinction ...
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(Universitat Pompeu Fabra, 2018-04-12)T-cell homeostasis must be tightly regulated and maintained in order to guarantee appropriate immune responses and prevent immunopathology. This maintenance depends on MHC-TCR interaction and cytokine-mediated signals among ...
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(Universitat Pompeu Fabra, 2018-07-13)The EBV has been linked to multiple human disease phenotypes and has been associated with cancers and other infections. Recently single gene analysis and genome-wide analysis studies have been exploited to uncover the human ...
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(Universitat Pompeu Fabra, 2016-03-11)Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the physical-chemistry variables ...
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(Universitat Pompeu Fabra, 2018-12-10)Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the ...
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(Universitat Pompeu Fabra, 2018-05-17)Rearrangements involving the mixed lineage leukemia gene (MLL) are found in majority of human infant leukemias (>60% of ALLs, 35% of AMLs) and are associated with dismal prognosis of these patients. They are also found in ...
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(Universitat Pompeu Fabra, 2021-09-10)Advanced societies have witnessed unprecedented socioeconomic and technological changes in the last 50 years. The growth of the service sector has transformed the class structure, and social mobility has increased for ...
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(Universitat Pompeu Fabra, 2017-02-08)The three chapters included in this dissertation aim to improve our understanding of the distance between people's desires regarding the timing and the number of children they want to have and what they finally achieve. ...
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(Universitat Pompeu Fabra, 2018-12-14)Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other hand, the study ...
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(Universitat Pompeu Fabra, 2019-12-11)La aplicación de la radiación ionizante (RI) en ámbito médico ha llegado, sin duda, para salvar vidas. Sin embargo, hay una preocupación entre los expertos de salud pública y protección radiológica con relación al incremento ...
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(Universitat Pompeu Fabra, 2020-02-03)Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula ...
Now showing items 3194-3213 of 3325
