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Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?

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dc.contributor.author Rondaan, Christien
dc.contributor.author Maso, Alessandra
dc.contributor.author Birlutiu, Rares-Mircea
dc.contributor.author Fernández Sampedro, Marta
dc.contributor.author Soriano, Alex
dc.contributor.author Diaz de Brito, Vicens
dc.contributor.author Gómez Junyent, Joan
dc.contributor.author Toro, María Dolores del
dc.contributor.author Hofstaetter, Jochen Gerhard
dc.contributor.author Salles, Mauro José
dc.contributor.author Esteban, Jaime
dc.contributor.author Wouthuyzen-Bakker, Marjan
dc.contributor.author ESCMID Study Group on Implant Associated Infections (ESGIAI)
dc.date.accessioned 2024-05-03T05:53:51Z
dc.date.available 2024-05-03T05:53:51Z
dc.date.issued 2023
dc.identifier.citation Rondaan C, Maso A, Birlutiu RM, Fernandez Sampedro M, Soriano A, Diaz de Brito V, et al. Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?. Clin Microbiol Infect. 2023 Nov;29(11):1431-6. DOI: 10.1016/j.cmi.2023.07.018
dc.identifier.issn 1198-743X
dc.identifier.uri http://hdl.handle.net/10230/59979
dc.description.abstract Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC. Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study. Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08). Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Clin Microbiol Infect. 2023 Nov;29(11):1431-6
dc.rights © 2023 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.cmi.2023.07.018
dc.subject.keyword Culture
dc.subject.keyword EBJIS
dc.subject.keyword Periprosthetic joint infection
dc.subject.keyword Single positive culture
dc.subject.keyword Sonication
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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