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Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy

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dc.contributor.author Fernández Rubio, Beatriz
dc.contributor.author Herrera Hidalgo, Laura
dc.contributor.author Luque Márquez, Rafael
dc.contributor.author de Alarcón, Arístides
dc.contributor.author López-Cortés, Luis E.
dc.contributor.author Luque Pardos, Sònia
dc.contributor.author Gutiérrez Urbón, José María
dc.contributor.author Fernández Polo, Antoni
dc.contributor.author Gil Navarro, María V.
dc.contributor.author Gutiérrez Valencia, Alicia
dc.date.accessioned 2024-04-24T06:42:30Z
dc.date.available 2024-04-24T06:42:30Z
dc.date.issued 2023
dc.identifier.citation Fernández-Rubio B, Herrera-Hidalgo L, Luque-Márquez R, de Alarcón A, López-Cortés LE, Luque-Pardos S, et al. Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy. Antibiotics (Basel). 2023 Feb 22;12(3):432. DOI: 10.3390/antibiotics12030432
dc.identifier.issn 2079-6382
dc.identifier.uri http://hdl.handle.net/10230/59879
dc.description.abstract Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for Enterococcus faecalis infective endocarditis. However, there is a lack of stability data for the combination of both drugs in elastomeric devices, so the inclusion of AC in Outpatient Parenteral Antimicrobial Therapy (OPAT) programs is challenging. The objective of the study was to determine the stability of AC in elastomeric pumps when stored at 8 ± 2 °C, 25 ± 2 °C, 30 ± 2 °C and 37 ± 2 °C using LC-MS/MS. The combination was diluted in 0.9% sodium chloride and the final concentrations were ampicillin 24 g/L plus ceftriaxone 8 g/L. Physical and chemical stability were evaluated at 12, 20, 24, 36 and 48 h after preparation. Stability was met at each time point if the percentage of intact drug was ≥90% of its respective baseline concentration and color and clearness remained unchanged. The drug combination was stable for 48 h when it was kept at 8 ± 2 °C. At 25 ± 2 °C and 30 ± 2 °C, they were stable for 24 h of storage. At 37 ± 2 °C, the stability criterion was not met at any time point. These results prove that AC could be included in OPAT programs using elastomeric infusion devices for the treatment of E. faecalis infections.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Antibiotics (Basel). 2023 Feb 22;12(3):432
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Stability of ampicillin plus ceftriaxone combined in elastomeric infusion devices for outpatient parenteral antimicrobial therapy
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/antibiotics12030432
dc.subject.keyword Stability
dc.subject.keyword Outpatient parenteral antimicrobial therapy
dc.subject.keyword Elastomers
dc.subject.keyword Ampicillin
dc.subject.keyword Ceftriaxone
dc.subject.keyword Infective endocarditis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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