dc.contributor.author |
Sisteré-Oró, Marta |
dc.contributor.author |
Du, Juan |
dc.contributor.author |
Wortmann, Diana D. J. |
dc.contributor.author |
Filippi, Marina D. |
dc.contributor.author |
Cañas-Ruano, Esperanza |
dc.contributor.author |
Arrieta Aldea, Itziar |
dc.contributor.author |
Marcos-Blanco, Agustín |
dc.contributor.author |
Castells, Xavier |
dc.contributor.author |
Grau Cerrato, Santiago |
dc.contributor.author |
García-Giralt, Natalia |
dc.contributor.author |
Perez-Zsolt, Daniel |
dc.contributor.author |
Boreika, Rytis |
dc.contributor.author |
Izquierdo-Useros, Nuria |
dc.contributor.author |
Güerri Fernández, Roberto |
dc.contributor.author |
Meyerhans, Andreas |
dc.date.accessioned |
2024-04-12T05:42:12Z |
dc.date.available |
2024-04-12T05:42:12Z |
dc.date.issued |
2024 |
dc.identifier.citation |
Sisteré-Oró M, Du J, Wortmann DDJ, Filippi MD, Cañas-Ruano E, Arrieta-Aldea I, et al. Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination. J Med Virol. 2024 Jan;96(1):e29317. DOI: 10.1002/jmv.29317 |
dc.identifier.issn |
0146-6615 |
dc.identifier.uri |
http://hdl.handle.net/10230/59743 |
dc.description.abstract |
People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose-sparing i.d. vaccination was superior to s.c. vaccination and promoted T-cell polyfunctionality, and the expression of the gut-homing marker α4β7 integrin on lymphocytes. HIV-1-infected individuals with CD4 T-cell counts ≤500/mm3 blood required at least a booster vaccination to exhibit efficient virus-specific T-cell responses. The magnitude of the Th1 response after this booster directly correlated with the CD4 T-cell count of the vaccinees. Further studies with a larger number of participants are warranted to confirm and expand our observations. |
dc.description.sponsorship |
This work received support and funding from Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) (grant number CB16/10/00245), Centro de Investigación Biomédica en Red Enfermedades Infecciosas, CIBERINFEC (CB21/13/00002), FEDER funds, FIS Project “PI19/00019” funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union, the Spanish Ministry of Science and Innovation grant number PID2022-141395OB-I00, and the “Unidad de Excelencia María de Maeztu,” funded by the MCIN and the AEI (DOI: 10.13039/501100011033). Nuria Izquierdo-Useros is supported by the Spanish Ministry of Science and Innovation (grant PID2020-117145RB-I00, Spain), EU HORIZON-HLTH-2021CORONA-01 (grant 101046118, European Union). |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Wiley |
dc.relation.ispartof |
J Med Virol. 2024 Jan;96(1):e29317 |
dc.rights |
© 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
dc.rights.uri |
http://creativecommons.org/licenses/by/4.0/ |
dc.title |
Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.1002/jmv.29317 |
dc.subject.keyword |
HIV-1-infected individuals |
dc.subject.keyword |
JYNNEOS vaccination |
dc.subject.keyword |
Monkeypox (mpox) |
dc.subject.keyword |
Pan-pox-specific T-cell responses |
dc.relation.projectID |
info:eu-repo/grantAgreement/EC/HE/101046118 |
dc.relation.projectID |
info:eu-repo/grantAgreement/ES/3PE/PID2022-141395OB-I00 |
dc.relation.projectID |
info:eu-repo/grantAgreement/ES/2PE/PID2020-117145RB-I00 |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/publishedVersion |