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Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination

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dc.contributor.author Sisteré-Oró, Marta
dc.contributor.author Du, Juan
dc.contributor.author Wortmann, Diana D. J.
dc.contributor.author Filippi, Marina D.
dc.contributor.author Cañas-Ruano, Esperanza
dc.contributor.author Arrieta Aldea, Itziar
dc.contributor.author Marcos-Blanco, Agustín
dc.contributor.author Castells, Xavier
dc.contributor.author Grau Cerrato, Santiago
dc.contributor.author García-Giralt, Natalia
dc.contributor.author Perez-Zsolt, Daniel
dc.contributor.author Boreika, Rytis
dc.contributor.author Izquierdo-Useros, Nuria
dc.contributor.author Güerri Fernández, Roberto
dc.contributor.author Meyerhans, Andreas
dc.date.accessioned 2024-04-12T05:42:12Z
dc.date.available 2024-04-12T05:42:12Z
dc.date.issued 2024
dc.identifier.citation Sisteré-Oró M, Du J, Wortmann DDJ, Filippi MD, Cañas-Ruano E, Arrieta-Aldea I, et al. Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination. J Med Virol. 2024 Jan;96(1):e29317. DOI: 10.1002/jmv.29317
dc.identifier.issn 0146-6615
dc.identifier.uri http://hdl.handle.net/10230/59743
dc.description.abstract People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose-sparing i.d. vaccination was superior to s.c. vaccination and promoted T-cell polyfunctionality, and the expression of the gut-homing marker α4β7 integrin on lymphocytes. HIV-1-infected individuals with CD4 T-cell counts ≤500/mm3 blood required at least a booster vaccination to exhibit efficient virus-specific T-cell responses. The magnitude of the Th1 response after this booster directly correlated with the CD4 T-cell count of the vaccinees. Further studies with a larger number of participants are warranted to confirm and expand our observations.
dc.description.sponsorship This work received support and funding from Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) (grant number CB16/10/00245), Centro de Investigación Biomédica en Red Enfermedades Infecciosas, CIBERINFEC (CB21/13/00002), FEDER funds, FIS Project “PI19/00019” funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union, the Spanish Ministry of Science and Innovation grant number PID2022-141395OB-I00, and the “Unidad de Excelencia María de Maeztu,” funded by the MCIN and the AEI (DOI: 10.13039/501100011033). Nuria Izquierdo-Useros is supported by the Spanish Ministry of Science and Innovation (grant PID2020-117145RB-I00, Spain), EU HORIZON-HLTH-2021CORONA-01 (grant 101046118, European Union).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof J Med Virol. 2024 Jan;96(1):e29317
dc.rights © 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/jmv.29317
dc.subject.keyword HIV-1-infected individuals
dc.subject.keyword JYNNEOS vaccination
dc.subject.keyword Monkeypox (mpox)
dc.subject.keyword Pan-pox-specific T-cell responses
dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101046118
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-141395OB-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-117145RB-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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