Welcome to the UPF Digital Repository

Refining critical structure contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark results and consensus guidelines from the STOPSTORM.eu consortium

Show simple item record

dc.contributor.author Balgobind, Brian V.
dc.contributor.author Algara López, Manuel-Ignacio
dc.contributor.author Blanck, Oliver
dc.date.accessioned 2024-03-26T07:26:16Z
dc.date.available 2024-03-26T07:26:16Z
dc.date.issued 2023
dc.identifier.citation Balgobind BV, Visser J, Grehn M, Marquard Knap M, de Ruysscher D, Levis M, et al. Refining critical structure contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark results and consensus guidelines from the STOPSTORM.eu consortium. Radiother Oncol. 2023 Dec;189:109949. DOI: 10.1016/j.radonc.2023.109949
dc.identifier.issn 0167-8140
dc.identifier.uri http://hdl.handle.net/10230/59580
dc.description.abstract Background and purpose: In patients with recurrent ventricular tachycardia (VT), STereotactic Arrhythmia Radioablation (STAR) shows promising results. The STOPSTORM.eu consortium was established to investigate and harmonise STAR treatment in Europe. The primary goals of this benchmark study were to standardise contouring of organs at risk (OAR) for STAR, including detailed substructures of the heart, and accredit each participating centre. Materials and methods: Centres within the STOPSTORM.eu consortium were asked to delineate 31 OAR in three STAR cases. Delineation was reviewed by the consortium expert panel and after a dedicated workshop feedback and accreditation was provided to all participants. Further quantitative analysis was performed by calculating DICE similarity coefficients (DSC), median distance to agreement (MDA), and 95th percentile distance to agreement (HD95). Results: Twenty centres participated in this study. Based on DSC, MDA and HD95, the delineations of well-known OAR in radiotherapy were similar, such as lungs (median DSC = 0.96, median MDA = 0.1 mm and median HD95 = 1.1 mm) and aorta (median DSC = 0.90, median MDA = 0.1 mm and median HD95 = 1.5 mm). Some centres did not include the gastro-oesophageal junction, leading to differences in stomach and oesophagus delineations. For cardiac substructures, such as chambers (median DSC = 0.83, median MDA = 0.2 mm and median HD95 = 0.5 mm), valves (median DSC = 0.16, median MDA = 4.6 mm and median HD95 = 16.0 mm), coronary arteries (median DSC = 0.4, median MDA = 0.7 mm and median HD95 = 8.3 mm) and the sinoatrial and atrioventricular nodes (median DSC = 0.29, median MDA = 4.4 mm and median HD95 = 11.4 mm), deviations between centres occurred more frequently. After the dedicated workshop all centres were accredited and contouring consensus guidelines for STAR were established. Conclusion: This STOPSTORM multi-centre critical structure contouring benchmark study showed high agreement for standard radiotherapy OAR. However, for cardiac substructures larger disagreement in contouring occurred, which may have significant impact on STAR treatment planning and dosimetry evaluation. To standardize OAR contouring, consensus guidelines for critical structure contouring in STAR were established.
dc.description.sponsorship The authors would like to thank all members of the STOPSTORM.eu consortium (see https://stopstorm.eu/en/consortium) and especially the credentialing and audit committee. We kindly thank the European Union’s Horizon-2020 research and innovation programme for funding this project under grant agreement No. 945119.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Radiother Oncol. 2023 Dec;189:109949
dc.rights © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Refining critical structure contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark results and consensus guidelines from the STOPSTORM.eu consortium
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.radonc.2023.109949
dc.subject.keyword Cardiac substructures
dc.subject.keyword Contouring benchmark
dc.subject.keyword Organs at risk (OAR)
dc.subject.keyword STereotactic Arrhythmia Radioablation (STAR)
dc.subject.keyword Stereotactic Body Radiotherapy (SBRT)
dc.subject.keyword Ventricular tachycardia (VT)
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945119
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking