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Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy

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dc.contributor.author Monteagudo-Gimeno, Eila
dc.contributor.author Sánchez-González, Roberto
dc.contributor.author Raduà Castaño, Joaquim
dc.contributor.author Fortea-González, Lydia
dc.contributor.author Boget Llucià, Teresa
dc.contributor.author Carreño Martínez, Mar
dc.contributor.author Donaire Pedraza, Antonio J.
dc.contributor.author Bargalló Alabart, Núria
dc.contributor.author Setoain Perego, Xavier
dc.contributor.author Rumià Arboix, Jordi
dc.contributor.author Bulbena Vilarrasa, Antonio
dc.contributor.author Pintor-Pérez, Luis
dc.date.accessioned 2024-03-01T07:31:04Z
dc.date.available 2024-03-01T07:31:04Z
dc.date.issued 2023
dc.identifier.citation Monteagudo-Gimeno E, Sánchez-González R, Raduà-Castaño J, Fortea-González L, Boget-Llucià T, Carreño-Martínez M, Donaire-Pedraza A, Bargalló-Alabart N, Setoain-Perego X, Rumià-Arboix J, Bulbena-Vilarrasa A, Pintor-Pérez L. Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy. Epilepsy Behav. 2023 Jul;144:109253. DOI: 10.1016/j.yebeh.2023.109253
dc.identifier.issn 1525-5050
dc.identifier.uri http://hdl.handle.net/10230/59300
dc.description.abstract Objective: This study aims to assess the prevalence of Interictal Dysphoric Disorder (IDD) in drug-resistant epilepsy (DRE) and to describe its clinical and psychopathological profile, including personality, as well as its impact on quality of life (QOL). Method: A retrospective cross-sectional study from an Epilepsy Unit from January 2007 to December 2017. All patients were diagnosed with DRE. Patients underwent a battery of tests (HADS, SCL-90R, PDQ-4+, QOLIE-31) and a psychiatrist assessed the presence of Axis-I disorders and IDD. Statistical procedures were carried out using R-4.0.1 software. Results: A total of 282 patients were included. A statistically significant association was found between IDD and mood and anxiety disorders (p < 0.001 and p < 0.05 respectively), and between IDD and higher scores in all HADS and SCL-90-R items compared to subjects without IDD (p < 0.001). A statistically significant association was also found between IDD and obsessive-compulsive, borderline and depressive personality disorder (p < 0.05). Scores in all QOLIE-31 items except for 'medication effects' were significantly lower in subjects with IDD compared with subjects without IDD (p < 0.001). Conclusions: In DRE, IDD subjects show differences in the psychopathological profile and QOL scores compared to subjects without a diagnosis of IDD. An early diagnosis of IDD could facilitate prompt interventions which might positively impact QOL.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Epilepsy Behav. 2023 Jul;144:109253
dc.rights © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Clinical relevance of interictal dysphoric disorder and its impact on quality of life in drug-resistant epilepsy
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.yebeh.2023.109253
dc.subject.keyword Drug-Resistant Epilepsy
dc.subject.keyword Interictal Dysphoric Disorder
dc.subject.keyword Psychopathology
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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