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International survey of antibiotic dosing and monitoring in adult intensive care units

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dc.contributor.author Williams, Paul G.
dc.contributor.author Tabah, Alexis
dc.contributor.author Cotta, Menino Osbert
dc.contributor.author Sandaradura, Indy
dc.contributor.author Kanji, Salmaan
dc.contributor.author Scheetz, Marc H.
dc.contributor.author Imani, Sahand
dc.contributor.author Elhadi, Muhammed
dc.contributor.author Luque Pardos, Sònia
dc.contributor.author Schellack, Natalie
dc.contributor.author Sanches, Cristina
dc.contributor.author Timsit, Jean-Francois
dc.contributor.author Xie, Jiao
dc.contributor.author Farkas, Andras
dc.contributor.author Wilks, Kathryn
dc.contributor.author Roberts, Jason A.
dc.contributor.author European Society of Intensive Care Medicine (ESICM)
dc.contributor.author ESCMID Study Group for Infections in Critically Ill Patients [ESGCIP]
dc.date.accessioned 2024-02-29T06:48:36Z
dc.date.available 2024-02-29T06:48:36Z
dc.date.issued 2023
dc.identifier.citation Williams PG, Tabah A, Cotta MO, Sandaradura I, Kanji S, Scheetz MH, Imani S, Elhadi M, Luque-Pardos S, Schellack N, Sanches C, Timsit JF, Xie J, Farkas A, Wilks K, Roberts JA; National Coordinators on behalf of the European Society of Intensive Care Medicine (ESICM) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Infections in Critically Ill Patients [ESGCIP]. International survey of antibiotic dosing and monitoring in adult intensive care units. Crit Care. 2023 Jun 19;27(1):241. DOI: 10.1186/s13054-023-04527-1
dc.identifier.issn 1364-8535
dc.identifier.uri http://hdl.handle.net/10230/59292
dc.description.abstract Background: In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These studies have led to the inclusion of dose optimization recommendations in international clinical practice guidelines. The last international survey describing dosing, administration and monitoring of commonly prescribed antibiotics for critically ill patients was published in 2015 (ADMIN-ICU 2015). This study aimed to describe the evolution of practice since this time. Methods: A cross-sectional international survey distributed through professional societies and networks was used to obtain information on practices used in the dosing, administration and monitoring of vancomycin, piperacillin/tazobactam, meropenem and aminoglycosides. Results: A total of 538 respondents (71% physicians and 29% pharmacists) from 409 hospitals in 45 countries completed the survey. Vancomycin was mostly administered as an intermittent infusion, and loading doses were used by 74% of respondents with 25 mg/kg and 20 mg/kg the most favoured doses for intermittent and continuous infusions, respectively. Piperacillin/tazobactam and meropenem were most frequently administered as an extended infusion (42% and 51%, respectively). Therapeutic drug monitoring was undertaken by 90%, 82%, 43%, and 39% of respondents for vancomycin, aminoglycosides, piperacillin/tazobactam, and meropenem, respectively, and was more frequently performed in high-income countries. Respondents rarely used dosing software to guide therapy in clinical practice and was most frequently used with vancomycin (11%). Conclusions: We observed numerous changes in practice since the ADMIN-ICU 2015 survey was conducted. Beta-lactams are more commonly administered as extended infusions, and therapeutic drug monitoring use has increased, which align with emerging evidence.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Crit Care. 2023 Jun 19;27(1):241
dc.rights © Crown 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title International survey of antibiotic dosing and monitoring in adult intensive care units
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s13054-023-04527-1
dc.subject.keyword Aminoglycosides
dc.subject.keyword Beta-lactams
dc.subject.keyword Drug monitoring
dc.subject.keyword Intensive care units
dc.subject.keyword Vancomycin
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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