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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

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dc.contributor.author Wang, Anqi
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Haiman, Christopher A.
dc.date.accessioned 2024-02-20T17:10:23Z
dc.date.issued 2023
dc.identifier.citation Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R et al. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet. 2023 Dec;55(12):2065-74. DOI: 10.1038/s41588-023-01534-4
dc.identifier.issn 1061-4036
dc.identifier.uri http://hdl.handle.net/10230/59184
dc.description.abstract The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Nat Genet. 2023 Dec;55(12):2065-74
dc.rights © Springer Nature Publishing AG [Wang A, Shen J, Rodriguez AA, Saunders EJ, Chen F, Janivara R et al. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants. Nat Genet. 2023 Dec;55(12):2065-74] [http://dx.doi.org/10.1038/s41588-023-01534-4]
dc.title Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41588-023-01534-4
dc.subject.keyword Genetics research
dc.subject.keyword Genome-wide association studies
dc.subject.keyword Preventive medicine
dc.subject.keyword Prostate cancer
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2024-05-09
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2024-05-09

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