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State of art of cancer pharmacogenomics in Latin American populations

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dc.contributor.author López-Cortés, Andrés
dc.contributor.author Guerrero, Santiago, 1957-
dc.contributor.author Redal, María Ana
dc.contributor.author Alvarado, Angel Tito
dc.contributor.author Quiñones, Luis
dc.date.accessioned 2024-02-20T07:25:48Z
dc.date.available 2024-02-20T07:25:48Z
dc.date.issued 2017
dc.identifier.citation López-Cortés A, Guerrero S, Redal MA, Alvarado AT, Quiñones LA. State of art of cancer pharmacogenomics in Latin American populations. International Journal of Molecular Sciences. 2017 Jun;18(6):639. DOI: 10.3390/ijms18060639
dc.identifier.issn 1422-0067
dc.identifier.uri http://hdl.handle.net/10230/59168
dc.description.abstract Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof International Journal of Molecular Sciences. 2017 Jun;18(6):639
dc.rights © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title State of art of cancer pharmacogenomics in Latin American populations
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijms18060639
dc.subject.keyword Cancer
dc.subject.keyword Single nucleotide polymorphism
dc.subject.keyword Precision medicine
dc.subject.keyword Latin America
dc.subject.keyword Pharmacogenetics
dc.subject.keyword Pharmacogenomics
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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