Show simple item record Guerra Moreno, Ángel Valcárcel, J. (Juan) 2024-02-13T07:19:03Z 2024-02-13T07:19:03Z 2023
dc.identifier.citation Guerra-Moreno Á, Valcárcel J. AI-assisted proofreading of RNA splicing. Genes Dev. 2023 Dec 26;37(21-24):945-7. DOI: 10.1101/gad.351373.123
dc.identifier.issn 0890-9369
dc.description.abstract RNA helicases orchestrate proofreading mechanisms that facilitate accurate intron removal from pre-mRNAs. How these activities are recruited to spliceosome/pre-mRNA complexes remains poorly understood. In this issue of Genes & Development, Zhang and colleagues (pp. 968-983) combine biochemical experiments with AI-based structure prediction methods to generate a model for the interaction between SF3B1, a core splicing factor essential for the recognition of the intron branchpoint, and SUGP1, a protein that bridges SF3B1 with the helicase DHX15. Interaction with SF3B1 exposes the G-patch domain of SUGP1, facilitating binding to and activation of DHX15. The model can explain the activation of cryptic 3' splice sites induced by mutations in SF3B1 or SUGP1 frequently found in cancer.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)
dc.relation.ispartof Genes Dev. 2023 Dec 26;37(21-24):945-7
dc.rights © 2023 Guerra-Moreno and Valcárcel; Published by Cold Spring Harbor Laboratory Press. This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at
dc.title AI-assisted proofreading of RNA splicing
dc.type info:eu-repo/semantics/article
dc.subject.keyword AlphaFold-Multimer
dc.subject.keyword DHX15
dc.subject.keyword G-patch
dc.subject.keyword Myelodysplastic syndromes
dc.subject.keyword Spliceosome mutations
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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