Welcome to the UPF Digital Repository

Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas

Show simple item record

dc.contributor.author Blanco-Carmona, Enrique
dc.contributor.author Narayanan, Ashwin
dc.contributor.author Hernandez, Inmaculada
dc.contributor.author Nieto, Juan C.
dc.contributor.author Elosua-Bayés, Marc
dc.contributor.author Sun, Xueyuan
dc.contributor.author Schmidt, Claudia
dc.contributor.author Pamir, Necmettin
dc.contributor.author Özduman, Koray
dc.contributor.author Herold-Mende, Christel
dc.contributor.author Pagani, Francesca
dc.contributor.author Cominelli, Manuela
dc.contributor.author Taranda, Julian
dc.contributor.author Wick, Wolfgang
dc.contributor.author von Deimling, Andreas
dc.contributor.author Poliani, Pietro Luigi
dc.contributor.author Rehli, Michael
dc.contributor.author Schlesner, Matthias
dc.contributor.author Heyn, Holger
dc.contributor.author Turcan, Sevin
dc.date.accessioned 2024-02-12T06:36:48Z
dc.date.available 2024-02-12T06:36:48Z
dc.date.issued 2023
dc.identifier.citation Blanco-Carmona E, Narayanan A, Hernandez I, Nieto JC, Elosua-Bayes M, Sun X, Schmidt C, Pamir N, Özduman K, Herold-Mende C, Pagani F, Cominelli M, Taranda J, Wick W, von Deimling A, Poliani PL, Rehli M, Schlesner M, Heyn H, Turcan S. Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas. Cell Rep Med. 2023 Nov 21;4(11):101249. DOI: 10.1016/j.xcrm.2023.101249
dc.identifier.issn 2666-3791
dc.identifier.uri http://hdl.handle.net/10230/59061
dc.description.abstract The isocitrate dehydrogenase (IDH) gene is recurrently mutated in adult diffuse gliomas. IDH-mutant gliomas are categorized into oligodendrogliomas and astrocytomas, each with unique pathological features. Here, we use single-nucleus RNA and ATAC sequencing to compare the molecular heterogeneity of these glioma subtypes. In addition to astrocyte-like, oligodendrocyte progenitor-like, and cycling tumor subpopulations, a tumor population enriched for ribosomal genes and translation elongation factors is primarily present in oligodendrogliomas. Longitudinal analysis of astrocytomas indicates that the proportion of tumor subpopulations remains stable in recurrent tumors. Analysis of tumor-associated microglia/macrophages (TAMs) reveals significant differences between oligodendrogliomas, with astrocytomas harboring inflammatory TAMs expressing phosphorylated STAT1, as confirmed by immunohistochemistry. Furthermore, inferred receptor-ligand interactions between tumor subpopulations and TAMs may contribute to TAM state diversity. Overall, our study sheds light on distinct tumor populations, TAM heterogeneity, TAM-tumor interactions in IDH-mutant glioma subtypes, and the relative stability of tumor subpopulations in recurrent astrocytomas.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cell Rep Med. 2023 Nov 21;4(11):101249
dc.rights © 2023 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.xcrm.2023.101249
dc.subject.keyword IDH mutation
dc.subject.keyword Astrocytoma
dc.subject.keyword Bone-marrow-derived macrophages
dc.subject.keyword Glioma
dc.subject.keyword Microglia
dc.subject.keyword Oligodendroglioma
dc.subject.keyword Recurrent glioma
dc.subject.keyword snATAC-seq
dc.subject.keyword snRNA-seq
dc.subject.keyword Tumor microenvironment
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking