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Sleep problems at ages 8-9 and ADHD symptoms at ages 10-11: evidence in three cohorts from INMA study

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dc.contributor.author González-Safont, Llúcia
dc.contributor.author Rebagliato, Marisa
dc.contributor.author Arregi, Ane
dc.contributor.author Carrasco, Paula
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Vegas, Oscar
dc.contributor.author Júlvez Calvo, Jordi
dc.contributor.author Estarlich, Marisa
dc.date.accessioned 2023-12-11T06:37:12Z
dc.date.available 2023-12-11T06:37:12Z
dc.date.issued 2023
dc.identifier.citation González-Safont L, Rebagliato M, Arregi A, Carrasco P, Guxens M, Vegas O, Julvez J, Estarlich M. Sleep problems at ages 8-9 and ADHD symptoms at ages 10-11: evidence in three cohorts from INMA study. Eur J Pediatr. 2023 Nov;182(11):5211-22. DOI: 10.1007/s00431-023-05145-3
dc.identifier.issn 0340-6199
dc.identifier.uri http://hdl.handle.net/10230/58466
dc.description.abstract Sleep problems and attention deficit hyperactivity disorder (ADHD) are interrelated during childhood and preadolescence. The objective of this work is assessing if sleep problems at ages 8-9 represent an alarm sign for presenting ADHD problems at ages 10-11 in three cohorts from INMA Study. Participants were 1244 children from Gipuzkoa, Sabadell, and Valencia cohorts. Sleep problems were assessed (ages 8-9) with the sleep items of the Child's Behaviour Checklist (CBCL), and ADHD problems were collected through the Conner's Parent Rating Scales-Revised: Short Form (CPRS-R:S) (age 10-11). Minimally and fully adjusted negative binomial models were fitted for each CPRS-R:S scale. Linearity of the relationship was assessed with generalized additive models (cubic smoothing splines with 2, 3, and 4 knots). For sensitivity analyses, children with previous symptoms, those born preterm and small for gestational age, and cases with extreme values, were excluded. Sleep problems presented IRR (95% CI) of 1.14 (1.10-1.19), 1.20 (1.14-1.26), 1.18 (1.11-1.25), and 1.18 (1.13-1.23) for opposition, inattention, hyperactivity, and ADHD scales, respectively. Fully adjusted models slightly decreased the IRR, but the association remained similar and significant. Sensitivity analyses showed similar results to fully adjusted models with only hyperactivity shown a slight decrease on significance (p = 0.051) when ADHD cases at age 9 were excluded. Conclusion: Sleep problems are an alarm sign for later neurodevelopment problems such as ADHD. Healthcare systems could take advantage implementing policies to pay special attention on the sleep habits and sleep hygiene. This could contribute to add evidence to public health programmes such as the Healthy Child Programme.
dc.description.sponsorship Funding for open access charge: CRUE-Universitat Jaume I. This study was funded by Grants from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5–1). EU Commission (261357, 308333, 603794 and 634453). Margarita Salas Grant MS21-125 and co-funded by European Union- Next Generation EU and Ministerio de Universidades. Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/1436, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/00090, PI09/02647, PI08/1151, PI11/01007, PI11/02591, PI11/02038, PI12/01890,PI13/1944, PI13/2032, PI13/02187, PI14/00891, PI14/01687, PI15/00118, PI16/1288, PI16/00261, PI17/00663, PI17/01340, PI18/00547, FIS-PI18/01237, and PI18/01142 incl. FEDER funds; Miguel Servet-FEDER CP11/00178, CP13/00054, CP15/00025, and CPII16/00051, CP16/00128, CP16/00118, CPII18/00018), CIBERESP. Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds). Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S). France: Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21). Comunitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), and Alicia Koplowitz Foundation 2017. Catalunya: Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430). Generalitat de Catalunya through the CERCA Program. Basque Country: Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Eur J Pediatr. 2023 Nov;182(11):5211-22
dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Sleep problems at ages 8-9 and ADHD symptoms at ages 10-11: evidence in three cohorts from INMA study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00431-023-05145-3
dc.subject.keyword ADHD
dc.subject.keyword Childhood
dc.subject.keyword Cohort study
dc.subject.keyword Preadolescence
dc.subject.keyword Sleep problems
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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