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Sleep duration and stress level in the risk of gastric cancer: A pooled analysis of case-Control studies in the Stomach Cancer Pooling (StoP) Project

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dc.contributor.author Collatuzzo, Giulia
dc.contributor.author Pelucchi, Claudio
dc.contributor.author Negri, Eva
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Huerta, José María
dc.contributor.author Vioque, Jesus
dc.contributor.author García de la Hera, Manuela
dc.contributor.author Tsugane, Shoichiro
dc.contributor.author Hamada, Gerson Shigueaki
dc.contributor.author Hidaka, Akihisa
dc.contributor.author Zhang, Zuo-Feng
dc.contributor.author Camargo, M. Constanza
dc.contributor.author Curado, Maria Paula
dc.contributor.author Lunet, Nuno
dc.contributor.author La Vecchia, Carlo
dc.contributor.author Boffetta, Paolo
dc.date.accessioned 2023-12-11T06:37:02Z
dc.date.available 2023-12-11T06:37:02Z
dc.date.issued 2023
dc.identifier.citation Collatuzzo G, Pelucchi C, Negri E, Kogevinas M, Huerta JM, Vioque J, de la Hera MG, Tsugane S, Shigueaki Hamada G, Hidaka A, Zhang ZF, Camargo MC, Curado MP, Lunet N, La Vecchia C, Boffetta P. Sleep duration and stress level in the risk of gastric cancer: A pooled analysis of case-Control studies in the Stomach Cancer Pooling (StoP) Project. Cancers (Basel). 2023 Aug 29;15(17):4319. DOI: 10.3390/cancers15174319
dc.identifier.issn 2072-6694
dc.identifier.uri http://hdl.handle.net/10230/58462
dc.description.abstract The association between sleep and stress and cancer is underinvestigated. We evaluated these factors in association with gastric cancer (GC). Five case-control studies from the Stomach Cancer Pooling (StoP) Project were included. We calculated the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for sleep duration and stress level in association with GC through multiple logistic regression models adjusted for several lifestyle factors. The analysis included 1293 cases and 4439 controls, 215 cardia and 919 noncardia GC, and 353 diffuse and 619 intestinal types. Sleep duration of ≥9 h was associated with GC (OR =1.57, 95% CI = 1.23-2.00) compared to 8 h. This was confirmed when stratifying by subsite (noncardia OR = 1.59, 95% CI = 1.22-2.08, and cardia OR = 1.63, 95% CI = 0.97-2.72) and histological type (diffuse OR = 1.65, 95% CI = 1.14-2.40 and intestinal OR = 1.24, 95% CI = 0.91-1.67). Stress was associated with GC (OR = 1.33, 95% CI = 1.18-1.50, continuous). This relationship was selectively related to noncardia GC (OR = 1.28, 95% 1.12-1.46, continuous). The risk of diffuse (OR = 1.32, 95% CI = 1.11-1.58) and intestinal type (OR = 1.23, 95% CI = 1.07-1.42) were higher when stress was reported. Results for the association between increasing level of stress and GC were heterogeneous by smoking and socioeconomic status (p for heterogeneity = 0.02 and <0.001, respectively). In conclusion, long sleep duration (≥9 h) was associated with GC and its subtype categories. Stress linearly increased the risk of GC and was related to noncardia GC.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Cancers (Basel). 2023 Aug 29;15(17):4319
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Sleep duration and stress level in the risk of gastric cancer: A pooled analysis of case-Control studies in the Stomach Cancer Pooling (StoP) Project
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/cancers15174319
dc.subject.keyword Cardia
dc.subject.keyword Circadian rhythm
dc.subject.keyword Gastric cancer
dc.subject.keyword Lifestyle
dc.subject.keyword Noncardia
dc.subject.keyword Sleep
dc.subject.keyword Sleep duration
dc.subject.keyword Stress.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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