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New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders

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dc.contributor.author Pol Cros, Maria
dc.contributor.author Mir-Pedrol, Júlia
dc.contributor.author Toloza, Lorena
dc.contributor.author Knödlseder, Nastassia
dc.contributor.author Maruotti, Julien
dc.contributor.author Zouboulis, Christos C.
dc.contributor.author Güell Cargol, Marc, 1982-
dc.contributor.author Fábrega, María José
dc.date.accessioned 2023-12-05T07:10:44Z
dc.date.available 2023-12-05T07:10:44Z
dc.date.issued 2023
dc.identifier.citation Cros MP, Mir-Pedrol J, Toloza L, Knödlseder N, Maruotti J, Zouboulis CC, Güell M, Fábrega MJ. New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders. Sci Rep. 2023 Sep 25;13(1):16058. DOI: 10.1038/s41598-023-43354-w
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/58442
dc.description.abstract Cutibacterium acnes (C. acnes) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been associated with the development of acne vulgaris, while other phylotypes have been linked to healthy skin. In this scenario, bacterial extracellular vesicles (EVs) play a role in the interkingdom communication role with the human host. The purpose of this study was to examine the impact of EVs generated by various phylotypes of C. acnes on inflammation and sebum production using different in vitro skin cell types. The main findings of this study reveal that the proteomic profile of the cargo embodied in the EVs reflects distinct characteristics of the different C. acnes phylotypes in terms of life cycle, survival, and virulence. The in vitro skin cell types showed an extended pro-inflammatory modulation of SLST A1 EVs consistently triggering the activation of the inflammation-related factors IL-8, IL-6, TNFα and GM-CSF, in comparison to SLST H1 and SLST H2. Additionally, an acne-prone skin model utilizing PCi-SEB and arachidonic acid as a sebum inducer, was employed to investigate the impact of C. acnes EVs on sebum regulation. Our findings indicated that all three types of EVs significantly inhibited sebum production after a 24-h treatment period, with SLST H1 EVs exhibiting the most pronounced inhibitory effect when compared to the positive control. The results of this study highlight the protective nature of C. acnes SLST H1 EVs and their potential use as a natural treatment option for alleviating symptoms associated with inflammation and oily skin.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Sci Rep. 2023 Sep 25;13(1):16058
dc.rights © The Author(s) 2023, corrected publication 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41598-023-43354-w
dc.subject.keyword Biotechnology
dc.subject.keyword Diseases
dc.subject.keyword Health care
dc.subject.keyword Immunology
dc.subject.keyword Microbiology
dc.subject.keyword Molecular biology
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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