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Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona

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dc.contributor.author López Seguí, Francesc, 1991-
dc.contributor.author Oyón Lerga, Unai
dc.contributor.author Laguna Marmol, Laura
dc.contributor.author Coll, Pep
dc.contributor.author Andreu, Angels
dc.contributor.author Meulbroek, Michael
dc.contributor.author López i Casasnovas, Guillem
dc.contributor.author Estrada Cuxart, Oriol
dc.contributor.author Ara Rey, Jordi
dc.contributor.author Quiñones, Carles; Pérez, Fèlix
dc.contributor.author Fernandez, Javier
dc.contributor.author Rivero, Àngel
dc.contributor.author Ricou Ríos, Laura
dc.contributor.author Clotet, Bonaventura
dc.date.accessioned 2023-11-27T11:28:18Z
dc.date.available 2023-11-27T11:28:18Z
dc.date.issued 2023
dc.identifier.citation López F, Oyón U, Laguna L, Coll P, Andreu A, Meulbroek M, et al. Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona. PLoS ONE. 2023 Jan 17;18(1):e0277571. DOI: 10.1371/journal.pone.0277571
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/58379
dc.description.abstract Introduction. Pre-Exposure Prophylaxis (PrEP) for HIV prevention has been implemented in several countries. Previous literature has shown that its cost-effectiveness (and, under some specifications, cost-saving character) is dependent on the reduction in price due to generics, the time-horizon and its effectiveness. The intervention has never been studied in Catalonia after the approval of the PrEP, a territory with extensive implementation. Methods. Economic evaluation of the implementation of HIV pre-exposition prophylaxis using administrative data from Men who have Sex with Men (MSM) who receive the treatment (at the generic price) compared with non-implementation. A deterministic compartmental model and a social perspective with a micro-costing approach over the time horizon 2022–2062 are used. A baseline 86% effectiveness of PrEP is assumed. Results. Daily oral PrEP is found to be cost-saving: discounted savings in costs are attained after 16 years, and after 40 years they reach 81 million euros. In terms of health indicators, 10,322 additional discounted QALYs are generated by the intervention. Results are sensitive to sexual behavioral patterns among MSM, the price of PrEP (reduced if offered on-demand), its effectiveness and the discount rate. Conclusions. The use and promotion of PrEP in Catalonia is predicted to result in substantial health and monetary benefits because of reductions in HIV infections. Short-term investments in the promotion of PrEP will result in important cost-savings in the long term.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2023 Jan 17;18(1):e0277571
dc.rights © 2023 López Seguí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Serologia
dc.subject.other VIH (Virus)
dc.subject.other Infeccions per VIH
dc.title Cost-effectiveness analysis of the daily HIV pre-exposure prophylaxis in men who have sex with men in Barcelona
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0277571
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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