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Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems

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dc.contributor.author Lozano, Manuel
dc.contributor.author Broberg, Karin
dc.contributor.author Soler Blasco, Raquel
dc.contributor.author Riutort-Mayol, Gabriel
dc.contributor.author Ballester Díez, Ferran
dc.contributor.author González-Safont, Llúcia
dc.contributor.author Murcia, Mario
dc.contributor.author Grimalt Obrador, Joan
dc.contributor.author Gil Hernández, Fernando
dc.contributor.author Olmedo, Pablo
dc.contributor.author Braeuer, Simone
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Irizar, Amaia
dc.contributor.author Lertxundi, Nerea
dc.contributor.author Zubero, Miren Begoña
dc.contributor.author Santa Marina, Loreto
dc.contributor.author Llop, Sabrina
dc.date.accessioned 2023-11-15T07:15:59Z
dc.date.available 2023-11-15T07:15:59Z
dc.date.issued 2023
dc.identifier.citation Lozano M, Broberg K, Soler-Blasco R, Riutort-Mayol G, Ballester F, González L, Murcia M, Grimalt JO, Gil F, Olmedo P, Braeuer S, Casas M, Guxens M, Irizar A, Lertxundi N, Santa Marina L, Llop S. Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems. Expo Health. 2023. DOI: 10.1007/s12403-023-00585-6
dc.identifier.issn 2451-9766
dc.identifier.uri http://hdl.handle.net/10230/58268
dc.description Data de publicació electrònica: 22-08-2023
dc.description.abstract Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) were measured in urine samples collected during pregnancy. Inorganic As metabolites were speciated in a subsample (n = 729). Emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL) composed of three scales: internalizing, externalizing and total problems. Sociodemographic, dietary and exposure to other environmental pollutants were obtained through questionnaires. Single nucleotide polymorphisms in brain- and metabolism-related genes APOE, BDNF, GSTP1, and PON1 were determined in cord blood. Multivariate negative binomial models were used. The interaction with sex and genotypes was evaluated including interaction terms. A multi-element analysis was carried out by a principal component analysis. Higher concentrations of Cu, monomethylarsonic acid, and Pb during pregnancy were associated with an increased incidence ratio risk (IRR) between 4.6 and 7.5% for internalizing and externalizing problems for all three CBCL scales in the children. Increasing Mo, Ni and Co concentrations were associated with higher IRR for internalizing problems (up to 8%), and Cd for externalizing problems (6.7%). Modifications by sex and genotypes were found for several associations. Multi-element analysis associated multiple metals and trace elements (Ni, Cu, Se, Cd and Pb) with higher internalizing problems.
dc.description.sponsorship This study was supported by grants from Spanish government through the Ministry of Universities under the grant CAS21/00008 and grant for the requalification of the Spanish University, financed by the European Union, NextGeneration EU, Instituto de Salud Carlos III [FIS-FEDER: 13/1944, 16/1288, 17/00663 and 19/1338; FIS-FSE: 17/00260; Miguel Servet-FSE: MSII20/0006, FIS-PI06/0867, FIS-PI09/00090, CPII18/00018], CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089, 2015111065), Generalitat Valenciana [BEST/2020/059, AICO/2020/285 and CIAICO/2021/132] and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221 and DFG 89/17). We also acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Expo Health. 2023
dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Prenatal metals exposure and pre-adolescents’ emotional and behavioral problems
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s12403-023-00585-6
dc.subject.keyword Metals
dc.subject.keyword Arsenic speciation
dc.subject.keyword Trace elements
dc.subject.keyword Emotional and behavioral problems
dc.subject.keyword Prenatal exposure
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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