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Roles of the physical environment in health-related quality of life in patients with chronic obstructive pulmonary disease

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dc.contributor.author Moitra, Subhabrata
dc.contributor.author Foraster Pulido, Maria, 1984-
dc.contributor.author Arbillaga Etxarri, Ane, 1986-
dc.contributor.author Marín, Alicia
dc.contributor.author Barberan-Garcia, Anael
dc.contributor.author Rodríguez Chiaradia, Diego Agustín
dc.contributor.author Balcells Vilarnau, Eva, 1967-
dc.contributor.author Koreny, Maria, 1972-
dc.contributor.author Torán Montserrat, Pere
dc.contributor.author Vall Casas, Pere
dc.contributor.author Rodríguez-Roisin, Robert
dc.contributor.author García Aymerich, Judith
dc.date.accessioned 2023-10-23T06:28:44Z
dc.date.available 2023-10-23T06:28:44Z
dc.date.issued 2022
dc.identifier.citation Moitra S, Foraster M, Arbillaga-Etxarri A, Marín A, Barberan-Garcia A, Rodríguez-Chiaradia DA, Balcells E, Koreny M, Torán-Monserrat P, Vall-Casas P, Rodríguez-Roisin R, Garcia-Aymerich J. Roles of the physical environment in health-related quality of life in patients with chronic obstructive pulmonary disease. Environ Res. 2022 Jan;203:111828. DOI: 10.1016/j.envres.2021.111828
dc.identifier.issn 0013-9351
dc.identifier.uri http://hdl.handle.net/10230/58111
dc.description.abstract Rationale: Many clinical and psychological factors are known to influence the health-related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD). However, research on whether environmental factors, such as air pollution, noise, temperature, and blue/green spaces also influence HRQL in COPD has not been systematically investigated. Objective: To assess the relationship between air pollution, road traffic noise, temperature, and distance to blue/green spaces and respiratory-specific HRQL in COPD. Methods: We used cross-sectional data from a multicenter study in 407 stable mild-to-very severe COPD patients from Barcelona (Catalonia). Patients answered the COPD Assessment Test (CAT) and Clinical COPD Questionnaire (CCQ). Individual residential exposure to air pollutants (nitrogen dioxide [NO2] and particulate matters of varying aerodynamic diameters [PM2.5, PM10, and PM2.5absorbance]), road traffic noise (Lden), and land surface temperature were estimated using long-term averages from land-use regression models, 24-h noise maps, and land surface temperature maps, respectively. We measured residential distances to blue/green spaces from the Urban Atlas. We used mixed-effect negative binomial (for CAT) and linear (for CCQ) regression models, adjusted for potential confounders, with a random effect by center. Results: Of those patients, 85 % were male and had a mean (SD) age of 69 (9) years, CAT score of 12 (7), CCQ-total score of 1.4 (1.0), and post-bronchodilator forced expiratory volume in 1 s (FEV1) of 57 (18) %predicted. We found that NO2 and PM2.5absorbance were associated with worsened CAT and CCQ-mental scores, e.g., 0.15-unit change in CAT score [regression coefficient (β) = 0.15; 95 % confidence interval (CI) = 0.03, 0.26] per interquartile range in NO2 [13.7 μg/m3]. Greater distances to blue/green spaces were associated with worsened CCQ-mental scores [0.08; 0.002, 0.15]. Conclusions: Our study showed that increased air pollution, particularly NO2 and PM2.5absorbance and greater distances to blue/green spaces negatively influence HRQL in COPD patients. These findings have important implications for the WHO promotion to develop healthy cities for our future.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Res. 2022 Jan;203:111828
dc.rights © Elsevier http://dx.doi.org/10.1016/j.envres.2021.111828
dc.title Roles of the physical environment in health-related quality of life in patients with chronic obstructive pulmonary disease
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2021.111828
dc.subject.keyword Air pollution
dc.subject.keyword Airflow limitation
dc.subject.keyword COPD
dc.subject.keyword Environment
dc.subject.keyword Quality of life
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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