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Early-childhood BMI trajectories in relation to preclinical cardiovascular measurements in adolescence

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dc.contributor.author Montazeri, Parisa, 1988-
dc.contributor.author Fossati, Serena
dc.contributor.author Clemente Batalha Pardal, Diana, 1990-
dc.contributor.author Cirugeda, Lourdes
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Fernández-Barrés, Sílvia
dc.contributor.author Fochs, Silvia
dc.contributor.author Garcia-Esteban, Raquel
dc.contributor.author Márquez, Sandra
dc.contributor.author Pey, Núria
dc.contributor.author Nawrot, Tim S.
dc.contributor.author Vrijheid, Martine
dc.date.accessioned 2023-10-20T06:06:47Z
dc.date.available 2023-10-20T06:06:47Z
dc.date.issued 2022
dc.identifier.citation Montazeri P, Fossati S, Clemente DBP, Cirugeda L, Elosua R, Fernández-Barrés S, Fochs S, Garcia-Esteban R, Marquez S, Pey N, Nawrot TS, Vrijheid M. Early-childhood BMI trajectories in relation to preclinical cardiovascular measurements in adolescence. J Dev Orig Health Dis. 2022 Jun;13(3):322-9. DOI: 10.1017/S2040174421000441
dc.identifier.issn 2040-1744
dc.identifier.uri http://hdl.handle.net/10230/58102
dc.description.abstract Cardiovascular diseases are the leading causes of morbidity and mortality. Overweight, obesity, and accelerated growth during early childhood have been associated with adverse cardiovascular outcomes in later life. Few studies have assessed whether trajectories of accelerated growth in early childhood are associated with preclinical cardiovascular measurements. We aimed to evaluate the associations between childhood body mass index (BMI) growth trajectories and measures of macro- and microvascular function in early adolescence. Measurements of macrovascular function (systolic and diastolic blood pressure (SBP and DBP), pulse wave velocity (PWV), and microvascular function (central retinal arteriolar/veinular equivalent) were assessed at 11 years old in a Spanish birth cohort study (n = 489). BMI trajectories from birth to 9 years were identified using latent class growth analysis. Multiple linear regression assessed the associations between the BMI trajectories and macro- and microvascular function. Compared to children with average birth size and slower BMI gain (reference), children with a lower birth size and accelerated BMI gain had increased SBP [β = 6.57; (95% CI 4.00, 9.15)], DBP [β = 3.65; (95% CI 1.45, 5.86)], and PWV [β = 0.14; (95% CI 0.01, 0.27)]. Children with higher birth size and accelerated BMI gain had increased SBP [β = 4.75; (95% CI 1.79, 7.71) compared to the reference. No significant associations between BMI trajectories and the microvascular measurements were observed. In conclusion, we found that childhood BMI trajectories characterized by accelerated growth are associated with preclinical macrovascular measurements in young adolescents.
dc.description.sponsorship The Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartof J Dev Orig Health Dis. 2022 Jun;13(3):322-9
dc.rights This article has been published in a revised form in Journal of developmental origins of health and disease [http://doi.org/10.1017/S2040174421000441]. This version is published under a Creative Commons CC-BY-NC-ND licence. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. © The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease.
dc.title Early-childhood BMI trajectories in relation to preclinical cardiovascular measurements in adolescence
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://doi.org/10.1017/S2040174421000441
dc.subject.keyword Growth
dc.subject.keyword Blood pressure
dc.subject.keyword Body mass index (BMI)
dc.subject.keyword Cardiovascular health
dc.subject.keyword Growth trajectories
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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