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dc.contributor.author Oliveras Cañellas, Núria
dc.contributor.author Castells-Nobau, Anna
dc.contributor.author Vega-Correa, Lisset de la
dc.contributor.author Latorre-Luque, Jessica
dc.contributor.author Motger-Albertí, Anna
dc.contributor.author Arnoriaga Rodríguez, María
dc.contributor.author Garre-Olmo, Josep
dc.contributor.author Zapata-Tona, Cristina
dc.contributor.author Coll Martínez, Clàudia
dc.contributor.author Ramió-Torrentà, Lluís
dc.contributor.author Moreno-Navarrete, José Maria
dc.contributor.author Puig, Josep
dc.contributor.author Villarroya, Francesc
dc.contributor.author Ramos, Rafel
dc.contributor.author Casadó-Anguera, Verònica
dc.contributor.author Martín García, Elena, 1975-
dc.contributor.author Maldonado, Rafael, 1961-
dc.contributor.author Mayneris Perxachs, Jordi
dc.contributor.author Fernández Real, Jose M.
dc.date.accessioned 2023-10-09T06:26:43Z
dc.date.available 2023-10-09T06:26:43Z
dc.date.issued 2023
dc.identifier.citation Oliveras-Cañellas N, Castells-Nobau A, de la Vega-Correa L, Latorre-Luque J, Motger-Albertí A, Arnoriaga-Rodriguez M, Garre-Olmo J, Zapata-Tona C, Coll-Martínez C, Ramió-Torrentà L, Moreno-Navarrete JM, Puig J, Villarroya F, Ramos R, Casadó-Anguera V, Martín-García E, Maldonado R, Mayneris-Perxachs J, Fernández-Real JM. Adipose tissue coregulates cognitive function. Sci Adv. 2023 Aug 11;9(32):eadg4017. DOI: 10.1126/sciadv.adg4017
dc.identifier.issn 2375-2548
dc.identifier.uri http://hdl.handle.net/10230/58058
dc.description.abstract Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance in different cognitive domains. These genes were mostly involved in synaptic function, phosphatidylinositol metabolism, the complement cascade, anti-inflammatory signaling, and vitamin metabolism. These findings were translated into the plasma metabolome. The circulating blood expression levels of most of these genes were also associated with several cognitive domains in a cohort of 816 participants. Targeted misexpression of candidate gene ortholog in the Drosophila fat body significantly altered flies memory and learning. Among them, down-regulation of the neurotransmitter release cycle-associated gene SLC18A2 improved cognitive abilities in Drosophila and in mice. Up-regulation of RIMS1 in Drosophila fat body enhanced cognitive abilities. Current results show previously unidentified connections between AT transcriptome and brain function in humans, providing unprecedented diagnostic/therapeutic targets in AT.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Association for the Advancement of Science (AAAS)
dc.relation.ispartof Sci Adv. 2023 Aug 11;9(32):eadg4017
dc.rights © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Adipose tissue coregulates cognitive function
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1126/sciadv.adg4017
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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