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Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii

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dc.contributor.author Regalado, Laura
dc.contributor.author Sario, Sara
dc.contributor.author Mendes, Rafael J.
dc.contributor.author Valle, Javier
dc.contributor.author Harvey, Peta J.
dc.contributor.author Teixeira, Cátia M.
dc.contributor.author Gomes, Paula
dc.contributor.author Andreu Martínez, David
dc.contributor.author Santos, Conceição
dc.date.accessioned 2023-10-03T06:16:37Z
dc.date.available 2023-10-03T06:16:37Z
dc.date.issued 2023
dc.identifier.citation Regalado L, Sario S, Mendes RJ, Valle J, Harvey PJ, Teixeira C, Gomes P, Andreu D, Santos C. Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii. Insects. 2023 Jun 7;14(6):533. DOI: 10.3390/insects14060533
dc.identifier.issn 2075-4450
dc.identifier.uri http://hdl.handle.net/10230/58021
dc.description.abstract The spotted-wing drosophila (Drosophila suzukii) is a polyphagous pest that causes severe damage and economic losses to soft-skinned fruit production. Current control methods are dominated by inefficient cultural practices and broad-spectrum insecticides that, in addition to having toxic effects on non-target organisms, are becoming less effective due to acquired resistance. The increasing awareness of the real impact of insecticides on health and the environment has promoted the exploration of new insecticidal compounds, addressing novel molecular targets. This study explores the efficacy of two orally delivered spider venom peptides (SVPs), J-atracotoxin-Hv1c (Hv1c) and µ-theraphotoxin-Hhn2b (TRTX), to manage D. suzukii, through survival assays and the evaluation of gene expression associated with detoxification pathways. Treatment with TRTX at 111.5 µM for 48 h enhanced fly longevity compared with the control group. Gene expression analysis suggests that detoxification and stress-related mechanisms, such as expression of P450 proteins and apoptotic stimuli signaling, are triggered in D. suzukii flies in response to these treatments. Our results highlight the potential interest of SVPs to control this pest, shedding light on how to ultimately develop improved target-specific formulations.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Insects. 2023 Jun 7;14(6):533
dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Towards a sustainable management of the spotted-wing drosophila: disclosing the effects of two spider venom peptides on Drosophila suzukii
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/insects14060533
dc.subject.keyword J-atracotoxin-Hv1c
dc.subject.keyword Gene expression
dc.subject.keyword Neurotoxic peptides
dc.subject.keyword Spotted-wing drosophila
dc.subject.keyword Stress-related pathways
dc.subject.keyword µ-theraphotoxin-Hhn2b
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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