Welcome to the UPF Digital Repository

Natural green spaces, sensitization to allergens, and the role of gut microbiota during infancy

Show simple item record

dc.contributor.author Buchholz, Vienna
dc.contributor.author Bridgman, Sarah L.
dc.contributor.author Nielsen, Charlene C.
dc.contributor.author Gascon Merlos, Mireia, 1984-
dc.contributor.author Tun, Hein M.
dc.contributor.author Simons, Elinor
dc.contributor.author Turvey, Stuart E.
dc.contributor.author Subbarao, Padmaja
dc.contributor.author Takaro, Tim K.
dc.contributor.author Brook, Jeffrey R.
dc.contributor.author Scott, James A.
dc.contributor.author Mandhane, Piush J.
dc.contributor.author Kozyrskyj, Anita L.
dc.date.accessioned 2023-09-21T07:01:40Z
dc.date.available 2023-09-21T07:01:40Z
dc.date.issued 2023
dc.identifier.citation Buchholz V, Bridgman SL, Nielsen CC, Gascon M, Tun HM, Simons E, Turvey SE, Subbarao P, Takaro TK, Brook JR, Scott JA, Mandhane PJ, Kozyrskyj AL. Natural green spaces, sensitization to allergens, and the role of gut microbiota during infancy. mSystems. 2023 Apr 27;8(2):e0119022. DOI: 10.1128/msystems.01190-22
dc.identifier.issn 2379-5077
dc.identifier.uri http://hdl.handle.net/10230/57932
dc.description.abstract The environment plays an instrumental role in the developmental origins of health and disease. Protective features of the environment in the development of asthma and atopy have been insufficiently studied. We used data from the CHILD (Canadian Healthy Infant Longitudinal Development) Cohort Study to examine relationships between living near natural green spaces in early infancy in Edmonton, AB, Canada and the development of atopic sensitization at 1 year and 3 years of age in a cohort of 699 infants, and whether these associations were mediated by infant gut microbiota (measured using 16s V4 amplicon sequencing) at 4 months. The Urban Planning Land Vegetation Index (uPLVI) map of the City of Edmonton was used to assess infants' exposure to natural spaces based on their home postal codes, and atopic sensitization was assessed using skin prink testing (SPTs) for common food and inhalant allergens. Our findings suggest there is a protective effect of natural green space proximity on the development of multiple inhalant atopic sensitizations at 3 years (odds ratio = 0.28 [95% CI 0.09, 0.90]). This relationship was mediated by changes to Actinobacteria diversity in infant fecal samples taken at 4 months. We also found a positive association between nature proximity and sensitization to at least one food or inhaled allergen; this association was not mediated by gut microbiota. Together, these findings underscore the importance of promoting natural urban greenspace preservation to improve child health by reducing atopic disease susceptibility. IMPORTANCE Our findings highlight the importance of preserving natural green space in urban settings to prevent sensitization to environmental allergens and promote early-life gut microbiota pathways to this health benefit. These findings support a mediating role of gut microbiome compositions in health and disease susceptibility. This study used unique, accurate, and comprehensive methodology to classify natural space exposure via a high-resolution topographical map of foliage subtypes within the City of Edmonton limits. These methods are improvements from other methods previously used to classify natural space exposure, such as the normalized density vegetation index from satellite imagery, which is not able to distinguish anthropogenic from green space. The use of these methods and the associations found between natural green space exposure and atopic sensitization outcomes support their use in future studies. Our findings also provide many avenues for future research including longer term follow up of this cohort and investigation of a causal role of reduced Actinobacteria diversity on atopic sensitization development.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartof mSystems. 2023 Apr 27;8(2):e0119022
dc.rights © 2023 Buchholz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Natural green spaces, sensitization to allergens, and the role of gut microbiota during infancy
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1128/msystems.01190-22
dc.subject.keyword Allergy
dc.subject.keyword Atopic sensitization
dc.subject.keyword Gut microbiome
dc.subject.keyword Gut microbiota
dc.subject.keyword Infant
dc.subject.keyword Infants
dc.subject.keyword Inhalant
dc.subject.keyword Microbiome
dc.subject.keyword Natural green space
dc.subject.keyword Natural space
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


In collaboration with Compliant to Partaking