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Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

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dc.contributor.author Thierry-Chef, Isabelle
dc.contributor.author Sarukhan, Adelaida
dc.contributor.author Ortiz, Rodney
dc.contributor.author Chumak, Vadim
dc.date.accessioned 2023-07-21T06:43:16Z
dc.date.available 2023-07-21T06:43:16Z
dc.date.issued 2023
dc.identifier.citation Thierry-Chef I, Timmermann B, Journy N, Bernier MO, McNally R, Dabin J, et al. Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project). EPJ Nuclear Sci Technol. 2023;9:22. DOI: 10.1051/epjn/2023009
dc.identifier.issn 2491-9292
dc.identifier.uri http://hdl.handle.net/10230/57631
dc.description.abstract The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.
dc.description.sponsorship The HARMONIC project has received funding from the Euratom research and training programme 2014–2018 under grant agreement No. 847707.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher EDP Sciences
dc.relation.ispartof EPJ Nuclear Sci Technol. 2023;9:22
dc.rights © I. Thierry-Chef et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri https://creativecommons.org/licenses/by/4.0
dc.title Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1051/epjn/2023009
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847707
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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