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The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states

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dc.contributor.author G-Guzmán, Elvira
dc.contributor.author Sanz Perl, Yonatan
dc.contributor.author Vohryzek, Jakub
dc.contributor.author Escrichs, Anira
dc.contributor.author Manasova, Dragana
dc.contributor.author Türker, Basak
dc.contributor.author Tagliazucchi, Enzo
dc.contributor.author Kringelbach, Morten L.
dc.contributor.author Sitt, Jacobo
dc.contributor.author Deco, Gustavo
dc.date.accessioned 2023-07-04T06:40:40Z
dc.date.available 2023-07-04T06:40:40Z
dc.date.issued 2023
dc.identifier.citation G-Guzmán E, Sanz Perl Y, Vohryzek J, Escrichs A, Manasova D, Türker B, Tagliazucchi E, Kringelbach M, Sitt JD, Deco G. The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states. Interface Focus. 2023;13(3):20220086. DOI: 10.1098/rsfs.2022.0086
dc.identifier.issn 2042-8898
dc.identifier.uri http://hdl.handle.net/10230/57448
dc.description.abstract Life is a constant battle against equilibrium. From the cellular level to the macroscopic scale, living organisms as dissipative systems require the violation of their detailed balance, i.e. metabolic enzymatic reactions, in order to survive. We present a framework based on temporal asymmetry as a measure of non-equilibrium. By means of statistical physics, it was discovered that temporal asymmetries establish an arrow of time useful for assessing the reversibility in human brain time series. Previous studies in human and non-human primates have shown that decreased consciousness states such as sleep and anaesthesia result in brain dynamics closer to the equilibrium. Furthermore, there is growing interest in the analysis of brain symmetry based on neuroimaging recordings and since it is a non-invasive technique, it can be extended to different brain imaging modalities and applied at different temporo-spatial scales. In the present study, we provide a detailed description of our methodological approach, paying special attention to the theories that motivated this work. We test, for the first time, the reversibility analysis in human functional magnetic resonance imaging data in patients suffering from disorder of consciousness. We verify that the tendency of a decrease in the asymmetry of the brain signal together with the decrease in non-stationarity are key characteristics of impaired consciousness states. We expect that this work will open the way for assessing biomarkers for patients' improvement and classification, as well as motivating further research on the mechanistic understanding underlying states of impaired consciousness.
dc.description.sponsorship Authors declare no competing interest. E.G.G. is supported by the Spanish Ministry of Universities for University Teacher Training Aid grant FPU 2020-02470. Y.S.P. is supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant 896354. J.V. is supported by the EU H2020 FET Proactive project Neurotwin grant agreement no. 101017716. A.E. is supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship programme. D.M. received individual funding from Ecole Doctorale Frontières de l’Innovation en Recherche et Education–Programme Bettencourt. B.T. received a PhD grant from the French Ministry of Higher Education and Ecole Normale Superieur. M.K. is supported by the Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and Centre for Eudaimonia and Human Flourishing at Linacre College funded by the Pettit and Carlsberg Foundations. G.D. is supported by the Spanish National Research project (AEI-PID2019-105772GB I00/AEI/10.13039/501100011033) funded by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). J.D.S. and E.T. are funded by a grant from STIC-AmSud [project SILIDOC - 21-STIC-11], ECOS-Sud A20M02, and ECOS-Sud U20S01. J.D.S. and G.D. are supported by the ModelDXConsciousness in the framework of the FLAG-ERA JTC 2021—HBP—2021 programme.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Royal Society
dc.relation.ispartof Interface Focus. 2023;13(3):20220086.
dc.rights © 2023 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1098/rsfs.2022.0086
dc.subject.keyword reversibility
dc.subject.keyword disorder of consciousness
dc.subject.keyword functional magnetic resonance imaging
dc.subject.keyword nonequilibrium
dc.subject.keyword temporal asymmetry
dc.subject.keyword arrow of time
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/896354
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101017716
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-105772GB-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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