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Long-term exposure to air pollution and COVID-19 vaccine antibody response in a general population cohort (COVICAT Study, Catalonia)

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dc.contributor.author Kogevinas, Manolis
dc.contributor.author Karachaliou, Marianna
dc.contributor.author Espinosa Díaz, Ana
dc.contributor.author Aguilar, Ruth
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author García Aymerich, Judith
dc.contributor.author Rubio, Rocío
dc.contributor.author Jiménez, Alfons
dc.contributor.author Vidal, Marta
dc.contributor.author Izquierdo, Luis
dc.contributor.author Cirach, Marta
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Dadvand, Payam
dc.contributor.author Straif, Kurt
dc.contributor.author Moncunill, Gemma
dc.contributor.author Dobaño, Carlota
dc.contributor.author Tonne, Cathryn
dc.date.accessioned 2023-06-30T06:44:03Z
dc.date.available 2023-06-30T06:44:03Z
dc.date.issued 2023
dc.identifier.citation Kogevinas M, Karachaliou M, Espinosa A, Aguilar R, Castaño-Vinyals G, Garcia-Aymerich J, et al. Long-term exposure to air pollution and COVID-19 vaccine antibody response in a general population cohort (COVICAT Study, Catalonia). Environ Health Perspect. 2023 Apr;131(4):47001. DOI: 10.1289/EHP11989
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/57415
dc.description.abstract Background: Ambient air pollution has been associated with COVID-19 disease severity and antibody response induced by infection. Objectives: We examined the association between long-term exposure to air pollution and vaccine-induced antibody response. Methods: This study was nested in an ongoing population-based cohort, COVICAT, the GCAT-Genomes for Life cohort, in Catalonia, Spain, with multiple follow-ups. We drew blood samples in 2021 from 1,090 participants of 2,404 who provided samples in 2020, and we included 927 participants in this analysis. We measured immunoglobulin M (IgM), IgG, and IgA antibodies against five viral-target antigens, including receptor-binding domain (RBD), spike-protein (S), and segment spike-protein (S2) triggered by vaccines available in Spain. We estimated prepandemic (2018-2019) exposure to fine particulate matter [PM ≤ 2.5μm in aerodynamic diameter (PM2.5)], nitrogen dioxide (NO2), black carbon (BC), and ozone (O3) using Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) models. We adjusted estimates for individual- and area-level covariates, time since vaccination, and vaccine doses and type and stratified by infection status. We used generalized additive models to explore the relationship between air pollution and antibodies according to days since vaccination. Results: Among vaccinated persons not infected by SARS-CoV-2 (n=632), higher prepandemic air pollution levels were associated with a lower vaccine antibody response for IgM (1 month post vaccination) and IgG. Percentage change in geometric mean IgG levels per interquartile range of PM2.5 (1.7μg/m3) were −8.1 (95% CI: −15.9, 0.4) for RBD,−9.9 (−16.2, −3.1) for S, and −8.4 (−13.5, −3.0) for S2. We observed a similar pattern for NO2 and BC and an inverse pattern for O3. Differences in IgG levels by air pollution levels persisted with time since vaccination. We did not observe an association of air pollution with vaccine antibody response among participants with prior infection (n=295). Discussion: Exposure to air pollution was associated with lower COVID-19 vaccine antibody response. The implications of this association on the risk of breakthrough infections require further investigation. https://doi.org/10.1289/EHP11989.
dc.description.sponsorship We acknowledge support from the Incentius a l’Avaluació de Centres CERCA (in_CERCA); EIT HEALTH BP2020-20873-Certify.Health; Fundació Privada Daniel Bravo Andreu; Spanish Ministry of Science & Innovation (PID2019-110810RB-I00 grant); the Spanish State Research Agency and Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), the Instituto de Salud Carlos III (PI17/01555) and the Generalitat de Catalunya through the CERCA Program. This study makes use of data generated by the GCAT-Genomes for Life. Cohort study of the Genomes of Catalonia, Fundació IGTP. IGTP is part of the CERCA Program/Generalitat de Catalunya. GCAT is supported by Acción de Dinamización del ISCIII-MINECO and the Department of Health of the Generalitat of Catalunya (ADE 10/00026); the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2017-SGR 529). G.M. is supported by RYC2020-029886-I/AEI/10.13039/501100011033, co-funded by European Social Fund. B.C. is supported by ISCIII national grant PI18/01512. R.R. is supported by the Health Department, Catalan Government (PERIS SLT017/20/000224). The full list of the investigators who contributed to the generation of the GCAT data is available from http://www.genomesforlife.com. Data are available from the authors.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences (NIEHS)
dc.relation.ispartof Environ Health Perspect. 2023 Apr;131(4):47001
dc.rights Reproduced with permission from Environmental Health Perspectives
dc.title Long-term exposure to air pollution and COVID-19 vaccine antibody response in a general population cohort (COVICAT Study, Catalonia)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/EHP11989
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110810RB-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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