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Y-Chromosome and mtDNA genetics reveal significant contrasts in affinities of modern Middle Eastern populations with European and African populations

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dc.contributor.author Badro, Danielle A.
dc.contributor.author Douaihy, Bouchra
dc.contributor.author Haber, Marc, 1980-
dc.contributor.author Youhanna, Sonia
dc.contributor.author Salloum, Angélique
dc.contributor.author Ghassibe-Sabbaghm, Michella
dc.contributor.author Johnsrud, Brian
dc.contributor.author Khazen, Georges
dc.contributor.author Matisoo Smith, Elizabeth
dc.contributor.author Soria Hernanz, David F.
dc.contributor.author Wells, R. Spencer
dc.contributor.author Tyler-Smith, Chris
dc.contributor.author Platt, Daniel E.
dc.contributor.author Zalloua, Pierre A.
dc.contributor.author Genographic Consortium
dc.date.accessioned 2023-06-26T06:02:50Z
dc.date.available 2023-06-26T06:02:50Z
dc.date.issued 2013
dc.identifier.citation Badro DA, Douaihy B, Haber M, Youhanna SC, Salloum A, Ghassibe-Sabbagh M, et al. Y-Chromosome and mtDNA genetics reveal significant contrasts in affinities of modern Middle Eastern populations with European and African populations. PLoS ONE. 2013 Jan 30;8(1):e54616. DOI: 10.1371/journal.pone.0054616
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/57336
dc.description.abstract The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent population movements created a striking genetic mosaic with distinct sex-based genetic differentiation. While prior studies have examined the mtDNA and Y-chromosome contrast in focal populations in the Middle East, none have undertaken a broad-spectrum survey including North and sub-Saharan Africa, Europe, and Middle Eastern populations. In this study 5,174 mtDNA and 4,658 Y-chromosome samples were investigated using PCA, MDS, mean-linkage clustering, AMOVA, and Fisher exact tests of FST's, RST's, and haplogroup frequencies. Geographic differentiation in affinities of Middle Eastern populations with Africa and Europe showed distinct contrasts between mtDNA and Y-chromosome data. Specifically, Lebanon's mtDNA shows a very strong association to Europe, while Yemen shows very strong affinity with Egypt and North and East Africa. Previous Y-chromosome results showed a Levantine coastal-inland contrast marked by J1 and J2, and a very strong North African component was evident throughout the Middle East. Neither of these patterns were observed in the mtDNA. While J2 has penetrated into Europe, the pattern of Y-chromosome diversity in Lebanon does not show the widespread affinities with Europe indicated by the mtDNA data. Lastly, while each population shows evidence of connections with expansions that now define the Middle East, Africa, and Europe, many of the populations in the Middle East show distinctive mtDNA and Y-haplogroup characteristics that indicate long standing settlement with relatively little impact from and movement into other populations.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2013 Jan 30;8(1):e54616
dc.rights © 2013 Badro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.subject.other ADN mitocondrial
dc.subject.other Cromosomes
dc.subject.other Genètica
dc.title Y-Chromosome and mtDNA genetics reveal significant contrasts in affinities of modern Middle Eastern populations with European and African populations
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0054616
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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