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Using pluripotent stem cells to understand normal and leukemic hematopoietic development

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dc.contributor.author Bigas Salvans, Anna
dc.contributor.author Galán i Palma, Luis
dc.contributor.author Kartha, Gayathri M.
dc.contributor.author Giorgetti, Alessandra
dc.date.accessioned 2023-05-12T06:21:41Z
dc.date.available 2023-05-12T06:21:41Z
dc.date.issued 2022
dc.identifier.citation Bigas A, Galán Palma L, Kartha GM, Giorgetti A. Using pluripotent stem cells to understand normal and leukemic hematopoietic development. Stem Cells Transl Med. 2022 Nov 18;11(11):1123-34. DOI: 10.1093/stcltm/szac071
dc.identifier.issn 2157-6564
dc.identifier.uri http://hdl.handle.net/10230/56788
dc.description.abstract Several decades have passed since the generation of the first embryonic stem cell (ESC) lines both in mice and in humans. Since then, stem cell biologists have tried to understand their potential biological and clinical uses for their implementation in regenerative medicine. The hematopoietic field was a pioneer in establishing the potential use for the development of blood cell products and clinical applications; however, early expectations have been truncated by the difficulty in generating bonafide hematopoietic stem cells (HSCs). Despite some progress in understanding the origin of HSCs during embryonic development, the reproduction of this process in vitro is still not possible, but the knowledge acquired in the embryo is slowly being implemented for mouse and human pluripotent stem cells (PSCs). In contrast, ESC-derived hematopoietic cells may recapitulate some leukemic transformation processes when exposed to oncogenic drivers. This would be especially useful to model prenatal leukemia development or other leukemia-predisposing syndromes, which are difficult to study. In this review, we will review the state of the art of the use of PSCs as a model for hematopoietic and leukemia development.
dc.description.sponsorship This work was funded by grants from PID2019-104695RB-I00 and PDC2021-120817-I00from AgenciaEstatal de Investigación (AEI) to AB, ERA PerMed GATA2-HuMo Funding Mechanism (Spain: Acció instrumental de SLT011/18/00006 and SLT011/18/00007 of the Department of Health of the Government of Catalonia to AG and A, the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO PID2020-15591RB-100), La Marató de TV3 (202001-32) and CERCA Programme/Generalitat de Catalunya for institutional support to AG. LGP is a recipient of 2021 FI_B2 00188, AGAUR, Generalitat de Cataluña.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Stem Cells Transl Med. 2022 Nov 18;11(11):1123-34
dc.rights © The Author(s) 2022. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Using pluripotent stem cells to understand normal and leukemic hematopoietic development
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/stcltm/szac071
dc.subject.keyword Adult hematopoietic stem cells
dc.subject.keyword Embryo
dc.subject.keyword Embryonic stem cells (ESCs)
dc.subject.keyword Hematologic malignancies
dc.subject.keyword Pluripotent stem cells
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-104695RB-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PDC2021-120817-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-15591RB-100
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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