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Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations

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dc.contributor.author Soler-Vidal, Joan
dc.contributor.author Fuentes-Claramonte, Paola
dc.contributor.author Salgado-Pineda, Pilar
dc.contributor.author Ramiro, Nuria
dc.contributor.author García-León, María Ángeles
dc.contributor.author Llanos Torres, María
dc.contributor.author Arévalo, Antonio
dc.contributor.author Guerrero-Pedraza, Amalia
dc.contributor.author Munuera, Josep
dc.contributor.author Sarró, Salvador
dc.contributor.author Salvador, Raymond
dc.contributor.author Hinzen, Wolfram
dc.contributor.author McKenna, Peter
dc.contributor.author Pomarol-Clotet, Edith
dc.date.accessioned 2023-03-14T07:16:44Z
dc.date.available 2023-03-14T07:16:44Z
dc.date.issued 2022
dc.identifier.citation Soler-Vidal J, Fuentes-Claramonte P, Salgado-Pineda P, Ramiro N, García-León MA, Llanos Torres M, Arévalo A, Guerrero-Pedraza A, Munuera J, Sarró S, Salvador R, Hinzen W, McKenna P, Pomarol-Clotet E. Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. PLoS One. 2022;17(12):e0276975. DOI: 10.1371/journal.pone.0276975
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/56220
dc.description.abstract The experience of auditory verbal hallucinations (AVH, “hearing voices”) in schizophrenia has been found to be associated with reduced auditory cortex activation during perception of real auditory stimuli like tones and speech. We re-examined this finding using 46 patients with schizophrenia (23 with frequent AVH and 23 hallucination-free), who underwent fMRI scanning while they heard words, sentences and reversed speech. Twenty-five matched healthy controls were also examined. Perception of words, sentences and reversed speech all elicited activation of the bilateral superior temporal cortex, the inferior and lateral prefrontal cortex, the inferior parietal cortex and the supplementary motor area in the patients and the healthy controls. During the sentence and reversed speech conditions, the schizophrenia patients as a group showed reduced activation in the left primary auditory cortex (Heschl’s gyrus) relative to the healthy controls. No differences were found between the patients with and without hallucinations in any condition. This study therefore fails to support previous findings that experience of AVH attenuates speech-perception-related brain activations in the auditory cortex. At the same time, it suggests that schizophrenia patients, regardless of presence of AVH, show reduced activation in the primary auditory cortex during speech perception, a finding which could reflect an early information processing deficit in the disorder.
dc.description.sponsorship This work was supported by the CIBERSAM and the Catalonian Government (2017SGR01271 to EP-C and 2017SGR1265 to WH). Also by a grant from the Plan Nacional de I+D+i 2013–2016: Juan de la Cierva-formación contract (FJCI-2015-25278 to PF-C) and two projects from the Ministerio de Ciencia, Innovación y Universidades (MCIU) y la Agencia Estatal de Investigación (AEI), FFI2016-77647-C2-2-P to WH and PS-P and PID2019-110120RBI00/AEI/10.13039/501100011033 to WH); and by the Instituto de Salud Carlos III, co-funded by European Union (ERDF/ESF, “Investing in your future”): Miguel Servet Research contracts (CPII13/00018 to RS and MS10/00596 to EP-C), Sara Borrell contract (CD19/00149 to PF-C) and Research Project Grants (PI18/00880 to PM).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One. 2022;17(12):e0276975.
dc.relation.isreferencedby https://doi.org/10.18112/openneuro.ds004302.v1.0.0
dc.relation.isreferencedby https://openneuro.org/datasets/ds004302
dc.relation.isreferencedby https://doi.org/10.1371/journal.pone.0276975.s001
dc.rights © 2022 Soler-Vidal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0276975
dc.subject.keyword Schizophrenia
dc.subject.keyword Auditory cortex
dc.subject.keyword Hallucinations
dc.subject.keyword Speech
dc.subject.keyword Sensory perception
dc.subject.keyword Occipital lobe
dc.subject.keyword Parietal lobe
dc.subject.keyword Prefrontal cortex
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110120RBI00
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FJCI-2015-25278
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FFI2016-77647-C2-2-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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