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Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents

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dc.contributor.author García-Moreno, Aracelys
dc.contributor.author Comerma-Montells, Albert
dc.contributor.author Tudela Pi, Marc
dc.contributor.author Minguillon, Jesus
dc.contributor.author Becerra Fajardo, Laura
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.date.accessioned 2023-03-06T07:33:27Z
dc.date.available 2023-03-06T07:33:27Z
dc.date.issued 2022
dc.identifier.citation García-Moreno A, Comerma-Montells A, Tudela-Pi M, Minguillon J, Becerra-Fajardo L, Ivorra A. Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents. J Neural Eng. 2022;19(5):056015. DOI: 10.1088/1741-2552/ac8dc4
dc.identifier.issn 1741-2560
dc.identifier.uri http://hdl.handle.net/10230/56053
dc.description.abstract Objective. To develop and in vivo demonstrate threadlike wireless implantable neuromuscular microstimulators that are digitally addressable. Approach. These devices perform, through its two electrodes, electronic rectification of innocuous high frequency current bursts delivered by volume conduction via epidermal textile electrodes. By avoiding the need of large components to obtain electrical energy, this approach allows the development of thin devices that can be intramuscularly implanted by minimally invasive procedures such as injection. For compliance with electrical safety standards, this approach requires a minimum distance, in the order of millimeters or a very few centimeters, between the implant electrodes. Additionally, the devices must cause minimal mechanical damage to tissues, avoid dislocation and be adequate for long-term implantation. Considering these requirements, the implants were conceived as tubular and flexible devices with two electrodes at opposite ends and, at the middle section, a hermetic metallic capsule housing the electronics. Main results. The developed implants have a submillimetric diameter (0.97 mm diameter, 35 mm length) and consist of a microcircuit, which contains a single custom-developed integrated circuit, housed within a titanium capsule (0.7 mm diameter, 6.5 mm length), and two platinum–iridium coils that form two electrodes (3 mm length) located at opposite ends of a silicone body. These neuromuscular stimulators are addressable, allowing to establish a network of microstimulators that can be controlled independently. Their operation was demonstrated in an acute study by injecting a few of them in the hind limb of anesthetized rabbits and inducing controlled and independent contractions. Significance. These results show the feasibility of manufacturing threadlike wireless addressable neuromuscular stimulators by using fabrication techniques and materials well established for chronic electronic implants. Although long-term operation still must be demonstrated, the obtained results pave the way to the clinical development of advanced motor neuroprostheses formed by dense networks of such wireless devices.
dc.description.sponsorship This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 724244). A.I. gratefully acknowledges the financial support by ICREA under the ICREA Academia programme.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IOP Publishing Ltd.
dc.relation.ispartof Journal of Neural Engineering. 2022;19(5):056015.
dc.rights © 2022 The Author(s). Published by IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1088/1741-2552/ac8dc4
dc.subject.keyword volume conduction
dc.subject.keyword microstimulators
dc.subject.keyword implants
dc.subject.keyword ASIC
dc.subject.keyword wireless power transfer
dc.subject.keyword hermeticity
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724244
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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