• Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease

  Alvarez Jerez, Pilar; Alcantud, Jose Luis; Reyes-Ramírez, Lucia de los; Moore, Anni; Ruz, Clara; Vives Montero, Francisco; Rodriguez-Losada, Noela; Saini, Prabhjyot; Gan-Or, Ziv; Alvarado, Chelsea X.; Makarious, Mary B.; Billingsley, Kimberley J.; Blauwendraat, Cornelis; Noyce, Alastair J.; Singleton, Andrew B.; Duran, Raquel; Bandres-Ciga, Sara (Nature Research, 2023)

  Neurodegeneration with brain iron accumulation (NBIA) represents a group of neurodegenerative disorders characterized by abnormal iron accumulation in the brain. In Parkinson's Disease (PD), iron accumulation is a cardinal ...
• Automated optimisation of solubility and conformational stability of antibodies and proteins

  Rosace, Angelo; Bennett, Anja; Oeller, Marc; Mortensen, Mie M.; Sakhnini, Laila; Lorenzen, Nikolai; Poulsen, Christian; Sormanni, Pietro (Nature Research, 2023)

  Biologics, such as antibodies and enzymes, are crucial in research, biotechnology, diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but their development is impeded by developability ...
• Robustness and innovation in synthetic genotype networks

  Santos-Moreno, Javier; Tasiudi, Eve; Kusumawardhani, Hadiastri; Stelling, Joerg; Schaerli, Yolanda (Nature Research, 2023)

  Genotype networks are sets of genotypes connected by small mutational changes that share the same phenotype. They facilitate evolutionary innovation by enabling the exploration of different neighborhoods in genotype space. ...
• Natural green spaces, sensitization to allergens, and the role of gut microbiota during infancy

  Buchholz, Vienna; Bridgman, Sarah L.; Nielsen, Charlene C.; Gascon Merlos, Mireia, 1984-; Tun, Hein M.; Simons, Elinor; Turvey, Stuart E.; Subbarao, Padmaja; Takaro, Tim K.; Brook, Jeffrey R.; Scott, James A.; Mandhane, Piush J.; Kozyrskyj, Anita L. (American Society for Microbiology, 2023)

  The environment plays an instrumental role in the developmental origins of health and disease. Protective features of the environment in the development of asthma and atopy have been insufficiently studied. We used data ...
• Analyzing the role of cancer-associated fibroblast activation on macrophage polarization

  Bruch Oms, Marina; Olivera-Salguero, Rubén, 1991-; Mazzolini, Rocco; Valle Pérez, Beatriz del; Mayo González, Paula; Beteta, Ángel; Peña Arranz, Raúl; García de Herreros, Antonio (Wiley, 2023)

  Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model ...
• Copy number variation on ABCC2-DNMBP loci affects the diversity and composition of the fecal microbiota in pigs

  Ramayo-Caldas, Yuliaxis; Crespo-Piazuelo, Daniel; Morata, Jordi; González-Rodríguez, Olga; Sebastià, Cristina; Castelló, Anna; Dalmau, Antoni; Ramos-Onsins, Sebastián; Alexiou, Konstantinos G.; Folch, Josep M.; Quintanilla, Raquel; Ballester Devís, Maria (American Society for Microbiology, 2023)

  Genetic variation in the pig genome partially modulates the composition of porcine gut microbial communities. Previous studies have been focused on the association between single nucleotide polymorphisms (SNPs) and the gut ...
• Which outcomes should be measured in hand eczema trials? Results from patient interviews and an expert survey

  Rönsch, Henriette; Schiffers, Frederike; Ofenloch, Robert; Weisshaar, Elke; Buse, Anna-Sophie; Hansen, Andreas; John, Swen Malte; Giménez Arnau, Anna Maria; Pesqué, David; Agner, Tove; Nørreslet, Line Brok; Loman, Laura; Romeijn, Geertruida L. E.; Schuttelaar, Marie-Louise A.; Košćec Bjelajac, Adrijana; Macan, Jelena; Bauer, Andrea; Apfelbacher, Christian J. (Wiley, 2023)

  Background: Hand eczema (HE) is a common skin disease characterized by itch, pain and visible skin changes such as fissures, erythema and vesicles. It is not yet clear which outcome domains are most important for patients. ...
• First experience of wave speed guided point-by-point cavo-tricuspid isthmus ablation for typical atrial flutter

  Vallès, Ermengol; Jiménez, Jesús; González, Carlos; Zaraket, Fatima; Rodríguez, Oriol; Llorca, Laia; Anguera, Ignasi; di Marco, Andrea; Fan, Roger; Casteigt, Benjamin (Springer, 2023)
• Why a complete response is the treatment aim in chronic spontaneous urticaria

  Bernstein, Jonathan A.; Giménez Arnau, Anna Maria; Maurer, Marcus; Staubach, Petra; Barbier, Nathalie; Hua, Eva; Severin, Thomas; Laires, Pedro A.; Balp, Maria Magdalena (MDPI, 2023)

  This study investigated the association between urticaria activity and health-related quality of life (HRQoL). Patient evaluations from the ligelizumab Phase 2b clinical trial (N = 382) were pooled (NCT02477332). Daily ...
• Beauveria bassiana rewires molecular mechanisms related to growth and defense in tomato

  Proietti, Silvia; Falconieri, Gaia Salvatore; Bertini, Laura; Pascale, Alberto; Bizzarri, Elisabetta; Morales Sanfrutos, Julia; Sabidó Aguadé, Eduard, 1981-; Ruocco, Michelina; Monti, Maurilia M.; Russo, Assunta; Dziurka, Kinga; Ceci, Marcello; Loreto, Francesco; Caruso, Carla (Oxford University Press, 2023)

  Plant roots can exploit beneficial associations with soil-inhabiting microbes, promoting growth and expanding the immune capacity of the host plant. In this work, we aimed to provide new information on changes occurring ...
• Electronic Cigarette Use in 12 European countries: results from the TackSHS survey

  Gallus, Silvano; Lugo, Alessandra; Stival, Chiara; Cerrai, Sonia; Clancy, Luke; Filippidis, Filippos T.; Gorini, Giuseppe; López, Maria José; López Nicolás, Ángel; Molinaro, Sabrina; Odone, Anna; Soriano, Joan B.; Tigova, Olena; van den Brandt, Piet A.; Vardavas, Constantine; Fernández, Esteve; TackSHS Project Investigators (Japan Epidemiological Association, 2023)

  Background: Limited data on electronic cigarette prevalence, patterns, and settings of use are available from several European countries. Methods: Within the TackSHS project, a face-to-face survey was conducted in 2017-2018 ...
• A longitudinal study of free leptin index in pre-eclamptic pregnancies

  Garcés, María Fernanda; Buell-Acosta, Julieth Daniela; Rodríguez-Navarro, Haiver Antonio; Páez-Leal, María Carolina; Maldonado-Acosta, Luis Miguel; Peralta-Franco, Jhon Jairo; Burgos-Cardenas, Álvaro Javier; Ángel-Müller, Edith; Parada-Baños, Arturo José; Parra-Pineda, Mario Orlando; Eslava-Schmalbach, Javier; Escobar-Sarmiento, Camilo Andrés; Lacunza, Ezequiel; Caminos-Cepeda, Sofia Alexandra; Castaño, Justo P.; Nogueiras, Ruben; Dieguez, Carlos; Ruiz-Parra, Ariel Iván; Caminos, Jorge Eduardo (Wiley, 2023)

  The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild ...
• Pushing the boundaries of deliberative constitutionalism: from judicial dialogue to inclusive dialogue

  Giuffré, C. Ignacio (Klub Revus. Centre for Studies on Democracy and European Constitutionality, 2023)

  Deliberative constitutionalism is a theory that has arrived at the centre of the academic debate in recent decades. Its novelty and interest lie in the fact that it offers a way to escape the objections to judicial review ...
• Identifying and explaining capacities as determinants of EP’s legislative outputs

  Arregui, Javier; Peñalver, Nereo (2023)

  Academics discovered their interest for the European Parliament only recently, when treaties increased the legislative competences of the institution. Until today, a comprehensive theory for the power structures and the ...
• Bridging the gap between website accessibility and lexicography: information access in online dictionaries

  Arias Badia, Blanca (Springer Nature, 2023)

  Information access has been one of the main concerns of lexicography since the frst dictionaries were compiled. This paper draws an explicit link between the proposals made from the felds of applied linguistics and website ...
• Why has epidemiology not (yet) succeeded in identifying the origin of the asthma epidemic?

  Antó i Boqué, Josep Maria; Pearce, Neil E.; Douwes, Jeroen; García Aymerich, Judith; Pembrey, Lucy; Richiardi, Lorenzo; Sunyer Deu, Jordi (Oxford University Press, 2023)
• Protein supplementation in a prehabilitation program in patients undergoing surgery for endometrial cancer

  Sole-Sedeno, Josep M.; Miralpeix, Ester; Muns, Maria Dolors; Rodriguez-Cosmen, Cristina; Fabregó, Berta; Kanjou, Nadwa; Medina, Francesc-Xavier; Mancebo Moreno, Gemma (MDPI, 2023)

  Enhanced recovery after surgery (ERAS) and prehabilitation programs are multidisciplinary care pathways to reduce stress response and improve perioperative outcomes, which also include nutritional interventions. The aim ...
• Association between malnutrition assessed by the global leadership initiative on malnutrition criteria and mortality in older people: a scoping review

  Sánchez-Rodríguez, María Dolores; De Meester, Dorien; Minon, Léa; Claessens, Marie; Gümüs, Neslian; Lieten, Siddhartha; Benoit, Florence; Surquin, Murielle; Marco Navarro, Ester (MDPI, 2023)

  The Global Leadership Initiative on Malnutrition (GLIM) criteria were introduced in 2018 for the diagnosis of malnutrition in adults. This review was aimed at gathering the evidence about the association between malnutrition ...
• A qualitative exploration of patient safety in a hospital setting in Spain: policy and practice recommendations on patients' and companions' participation

  Abiétar, Daniel G.; Domingo, Laia; Medina Perucha, Laura; Saavedra, Nuria; Berenguera, Anna; Lacueva-Pérez, Laia; Hurtado, Marta; Castells, Xavier; Sala, Maria (Wiley, 2023)

  Introduction: Patients' and companions' participation in healthcare could help prevent adverse events, which are a significant cause of disease and disability. Before designing interventions to increase participation, it ...
• Characterising the treatment of thromboembolic events after COVID-19 vaccination in 4 European countries and the US: an international network cohort study

  Markus, Aniek F.; Strauss, Victoria Y.; Burn, Edward; Li, Xintong; Delmestri, Antonella; Reich, Christian; Yin, Can; Mayer, Miguel Ángel, 1960-; Ramírez Anguita, Juan Manuel; Marti, Edelmira; Verhamme, Katia M. C.; Rijnbeek, Peter; Prieto-Alhambra, Daniel; Jödicke, Annika M. (Frontiers, 2023)

  Background: Thrombosis with thrombocytopenia syndrome (TTS) has been identified as a rare adverse event following some COVID-19 vaccines. Various guidelines have been issued on the treatment of TTS. We aimed to characterize ...

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