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  • Callegaro, Giulia; Kunnen, Steven J.; Trairatphisan, Panuwat; Grosdidier, Solène; Niemeijer, Marije; den Hollander, Wouter; Guney, Emre; Piñero González, Janet, 1977-; Furlong, Laura I.; Webster, Yue W.; Saez-Rodriguez, Julio; Sutherland, Jeffrey J.; Mollon, Jennifer; Stevens, James L.; van de Water, Bob (SpringerOpen, 2021)
    Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing ...
  • Fernández de la Puente, María; Hernández-Alonso, Pablo; Canudas i Puig, Sílvia; Martí, Amelia; Fitó Colomer, Montserrat; Razquin, Cristina; Salas Salvadó, Jordi (MDPI, 2021)
    Telomere length (TL) has been associated with aging and is determined by lifestyle. However, the mechanisms by which a dietary pattern such as the Mediterranean diet (MedDiet) affects TL homeostasis are still unknown. Our ...
  • Cucarull-Martínez, Blanca; Tutusaus, Anna; Hernáez-Alsina, Tania; García de Frutos, Pablo; Reig, María; Colell, Anna; Marí, Montserrat; Morales, Albert (MDPI, 2021)
    Sorafenib and regorafenib, multikinase inhibitors (MKIs) used as standard chemotherapeutic agents for hepatocellular carcinoma (HCC), generate reactive oxygen species (ROS) during cancer treatment. Antioxidant supplements ...
  • Ibarluzea, Jesús; Gallastegi, Mara; Santa Marina, Loreto; Jiménez-Zabala, Ana; Arranz, Enrique; Molinuevo, Amaia; Lopez-Espinosa, Maria-José; Ballester Díez, Ferran; Villanueva, Cristina M.; Riano-Galan, Isolina; Sunyer Deu, Jordi; Tardón, Adonina; Lertxundi, Aitana (Elsevier, 2022)
    Background: Cross-sectional and prospective studies have provided evidence of the neurotoxic effect of early exposure to fluoride (F) in pregnancy. It has been negatively associated with cognitive development during ...
  • Grimalt Obrador, Joan; Garí de Barbarà, Mercè, 1982-; Santa Marina, Loreto; Ibarluzea, Jesús; Sunyer Deu, Jordi (Elsevier, 2022)
    Background: Transplacental transfer and breastfeeding are the main transport routes of organic pollutants into children at the beginning of life. Although pollutant transmission through these mechanisms primarily depends ...
  • Ponjoan, Anna; Blanch, Jordi; Alves-Cabratosa, Lia; Martí-Lluch, Ruth; Comas Cufí, Marc; Cirach, Marta; Nieuwenhuijsen, Mark J.; Garcia Gil, Maria; Ramos, Rafel (Elsevier, 2022)
    Living in urban areas with abundant greenness might provide health benefits in general population. Literature suggests that sex/gender plays a role in the association between greenness and health outcomes. But the impact ...
  • Anabitarte Riol, Asier; Ibarluzea, Jesús; García-Baquero, Gonzalo; Santa Marina, Loreto; Fernández-Somoano, Ana; Tardón, Adonina; Nieuwenhuijsen, Mark J.; de Castro, Montserrat; Dadvand, Payam; Lertxundi, Aitana (Elsevier, 2022)
    In an urbanizing world, with 55% of the population living in cities, it is essential to design friendly and healthy ones. An emerging body of evidence has associated greenspace exposure with improved cognitive development, ...
  • Lozano, Manuel; Vrijheid, Martine; Bustamante Pineda, Mariona; Llop, Sabrina (Elsevier, 2022)
    Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg ...
  • Halonen, Jaana I.; Kogevinas, Manolis; Nieuwenhuijsen, Mark J.; Antó i Boqué, Josep Maria (Elsevier, 2021)
    In 2015, the Rockefeller Foundation-Lancet Commission launched a report introducing a novel approach called Planetary Health and proposed a concept, a strategy and a course of action. To discuss the concept of Planetary ...
  • Martínez-Riaño, Ana; Bovolenta, Elena R.; Boccasavia, Viola L.; Ponomarenko, Julia; Abia, David; Oeste, Clara L.; Fresno, Manuel; van Santen, Hisse M.; Alarcon, Balbino (Rockefeller University Press, 2019)
    Signal strength controls the outcome of αβ T cell selection in the thymus, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is above the ...
  • Pérez-Pérez, Martin; Pérez-Rodríguez, Gael; Blanco-Míguez, Aitor; Fdez-Riverola, Florentino; Valencia, Alfonso; Krallinger, Martin; Lourenço, Anália (Springer, 2019)
    Background: Shared tasks and community challenges represent key instruments to promote research, collaboration and determine the state of the art of biomedical and chemical text mining technologies. Traditionally, such ...
  • Castilla-Vallmanya, Laura; Gürsoy, Semra; Bozkaya, Özlem Giray; Prats-Planas, Aina; Bullich, Gemma; Matalonga, Leslie; Centeno-Pla, Mónica; Rabionet Janssen, Raquel; Grinberg, Daniel; Balcells, Susana; Urreizti, Roser (MDPI, 2021)
    We present a Turkish family with two cousins (OC15 and OC15b) affected with syndromic developmental delay, microcephaly, and trigonocephaly but with some phenotypic traits distinct between them. OC15 showed asymmetrical ...
  • Mateo, Lidia; Duran-Frigola, Miquel, 1985-; Gris-Oliver, Albert; Palafox, Marta; Scaltriti, Maurizio; Razavi, Pedram; Chandarlapaty, Sarat; Arribas, Joaquín; Bellet, Meritxell; Serra, Violeta; Aloy, Patrick, 1972- (BioMed Central, 2020)
    Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence ...
  • Baud, Amelie; Casale, Francesco Paolo; Barkley-Levenson, Amanda M.; Farhadi, Nilgoun; Montillot, Charlotte; Yalcin, Binnaz; Nicod, Jerome; Palmer, Abraham A.; Stegle, Oliver (BioMed Central, 2021)
    Background: The phenotype of an individual can be affected not only by the individual's own genotypes, known as direct genetic effects (DGE), but also by genotypes of interacting partners, indirect genetic effects (IGE). ...
  • Dolgova, Olga; Lao Grueso, Oscar, 1976- (MDPI, 2018)
    Evolutionary medicine applies the principles of evolutionary biology to understand why we get sick rather than how, and it has undergone an exponential growth since the early 1990s [...].
  • Faure, Andre J.; Domingo, Júlia; Schmiedel, Jörn M.; Hidalgo-Carcedo, Cristina; Diss, Guillaume; Lehner, Ben, 1978- (2022)
    Allosteric communication between distant sites in proteins is central to biological regulation but still poorly characterized, limiting understanding, engineering and drug development1-6. An important reason for this is ...
  • Ellena, Marta; Ballester, Joan; Mercogliano, Paola; Ferracin, Elisa; Barbato, Giuliana; Costa, Giuseppe; Ingole, Vijendra (BioMed Central, 2020)
    Background: Understanding context specific heat-health risks in urban areas is important, especially given anticipated severe increases in summer temperatures due to climate change effects. We investigate social inequalities ...
  • Drakvik, Elina; Kogevinas, Manolis; Bergman, Åke; Devouge, Anais; Barouki, Robert; HERA (Health and Environment Research Agenda) Consortium (BioMed Central, 2022)
    Climate change, urbanisation, chemical pollution and disruption of ecosystems, including biodiversity loss, affect our health and wellbeing. Research is crucial to be able to respond to the current and future challenges ...
  • Howe, Caitlin G.; Margetaki, Katerina; Vafeiadi, Marina, 1983-; Roumeliotaki, Theano; Karachaliou, Marianna; Kogevinas, Manolis; McConnell, Rob; Eckel, Sandrah P.; Conti, David V.; Kippler, Maria; Farzan, Shohreh F.; Chatzi, Leda (BioMed Central, 2021)
    Background: Child blood pressure (BP) is predictive of future cardiovascular risk. Prenatal exposure to metals has been associated with higher BP in childhood, but most studies have evaluated elements individually and ...
  • Gignac, Florence; Righi, Valeria; Toran, Raül; Errandonea, Lucía Paz; Ortiz, Rodney; Nieuwenhuijsen, Mark J.; Creus, Javier; Basagaña Flores, Xavier; Balestrini, Mara (BioMed Central, 2022)
    Background: While the health risks of air pollution attract considerable attention, both scholarly and within the general population, citizens are rarely involved in environmental health research, beyond participating as ...

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