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Visualitza Recerca: articles, congressos, llibres per matèria "Virology"

Ara mostrant els elements 1-6 de 6

Early detection and improved genomic surveillance of SARS-CoV-2 variants from deep sequencing data

Ramazzotti, Daniele; Maspero, Davide; Angaroni, Fabrizio; Spinelli, Silvia; Antoniotti, Marco; Piazza, Rocco; Graudenzi, Alex (Elsevier, 2022)

A key task of genomic surveillance of infectious viral diseases lies in the early detection of dangerous variants. Unexpected help to this end is provided by the analysis of deep sequencing data of viral samples, which are ...
Innate cell-mediated cytotoxic activity of European sea bass leucocytes against nodavirus-infected cells: a functional and RNA-seq study

Chaves Pozo, Elena; Valero, Yulema; Esteve-Codina, Anna; Gómez Garrido, Jèssica; Dabad, Marc; Alioto, Tyler; Meseguer, José; Esteban, María Ángeles; Cuesta, Alberto (Nature Publishing Group, 2017)

Nervous necrosis virus (NNV) causes high mortalities in several marine species. We aimed to evaluate the innate cell-mediated cytotoxic (CMC) activity of head-kidney leucocytes (HKLs) isolated from naïve European sea bass ...
N6-methyladenosine modification is not a general trait of viral RNA genomes

Baquero Pérez, Belinda; Yonchev, Ivaylo D.; Delgado-Tejedor, Anna; Medina, Rebeca; Puig-Torrents, Mireia; Sudbery, Ian; Begik, Oguzhan; Wilson, Stuart A.; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2024)

Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these ...
PACIFIC: a lightweight deep-learning classifier of SARS-CoV-2 and co-infecting RNA viruses

Acera Mateos, Pablo; Balboa, Renzo F.; Easteal, Simon; Eyras Jiménez, Eduardo; Patel, Hardip R. (Nature Research, 2021)

Viral co-infections occur in COVID-19 patients, potentially impacting disease progression and severity. However, there is currently no dedicated method to identify viral co-infections in patient RNA-seq data. We developed ...
Single-virus genomics reveals hidden cosmopolitan and abundant viruses

Martínez Hernández, Francisco; Fornas Carreño, Oscar; Lluesma Gómez, Mónica; Bolduc, Benjamin; de la Cruz Peña, María Jose; Martínez Martínez, Joaquín; Antón, Josefa; Gasol, Josep M.; Rosselli, Riccardo; Rodríguez Valera, Francisco; Sullivan, Matthew; Acinas, Silvia G.; Martínez García, Manuel (Nature Publishing Group, 2017)

Microbes drive ecosystems under constraints imposed by viruses. However, a lack of virus genome information hinders our ability to answer fundamental, biological questions concerning microbial communities. Here we apply ...
Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations

Solé Vicente, Ricard, 1962-; Sardanyés i Cayuela, Josep; Simó, Carles; Martínez, Regina; Elena, Santiago F. (Nature Publishing Group, 2014)

The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic ...