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BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice

Aso Pérez, Ester; Valverde Granados, Olga; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Pazos, Ángel; Ledent, Catherine; Valdizán, Elsa M. (Wiley-Blackwell, 2008)

Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate ...
Increased opioid dependence in a mouse model of panic disorder

Gallego, Xavier; Murtra, Patricia; Zamalloa, Teresa; Canals, Josep Maria; Pineda, Joseba; Amador Arjona, Alejandro; Maldonado, Rafael, 1961-; Dierssen, Mara (Frontiers, 2010)

Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high-affinity receptor for neurotrophin-3, is a key molecule involved in ...