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Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast

Zuin, Alice, 1978-; Gabrielli, Natalia, 1978-; Calvo, Isabel A.; García Santamarina, Sarela, 1978-; Hoe, Kwang-Lae; Kim, Dong Uk; Park, Han-Oh; Hayles, Jacqueline; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2008)

Background: Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. Methodology/Principal Findings: We analyzed ...