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Visualitza Recerca: articles, congressos, llibres per matèria "Bladder cancer"

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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta Trull, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
A review on the evolution of PD-1/PD-L1 immunotherapy for bladder cancer: the future is now

Bellmunt Molins, Joaquim, 1959-; Powles, Thomas; Vogelzang, Nicholas J. (Elsevier, 2017)

The treatment of bladder cancer has evolved over time to encompass not only the traditional modalities of chemotherapy and surgery, but has been particularly impacted by the use of immunotherapy. The first immunotherapy ...
A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background

García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)

The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Lindskrog, Sia Viborg; Real, Francisco X.; Dyrskjøt, Lars (Nature Research, 2021)

The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients ...
Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR

Dyrskjøt, Lars; Reinert, Thomas; Novoradovsky, Alexey; Zuiverloon, Tahlita CM; Beukers, Willemien; Zwarthoff, Ellen; Malats i Riera, Núria; Real, Francisco X.; Segersten, Ulrika; Malmström, Per-Uno; Knowles, Megan; Hurst, Carolyn; Sorge, Joseph; Borre, Michael (Cancer Research UK, 2012)

Background: Multiple clinical risk factors and genetic profiles have been demonstrated to predict progression of non-muscle invasive bladder cancer; however, no easily clinical applicable gene signature has been developed ...
Avelumab first-line maintenance in locally advanced or metastatic urothelial carcinoma: Applying clinical trial findings to clinical practice

Grivas, Petros; Agarwal, Neeraj; Pal, Sumanta; Kalebasty, Arash Rezazadeh; Sridhar, Srikala S.; Smith, Jodi; Devgan, Geeta; Sternberg, Cora N.; Bellmunt Molins, Joaquim, 1959- (Elsevier, 2021)

Although urothelial carcinoma (UC) is considered a chemotherapy-sensitive tumor, progression-free survival and overall survival (OS) are typically short following standard first-line (1L) platinum-containing chemotherapy ...
Bladder cancer and reproductive factors among women in Spain

Huang, An-Tsun; Kogevinas, Manolis; Silverman, Debra T.; Malats i Riera, Núria; Rothman, Nathaniel; Tardón, Adonina; Serra, Consol; García Closas, Reina; Carrato, Alfredo; Cantor, Kenneth P (Springer, 2009)

Hormonal factors, possibly related to reproductive characteristics, may play a role in the risk of bladder cancer among women. To study this, we investigated the effects of reproductive factors on female bladder cancer ...
Bladder cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Powles, Thomas; Bellmunt Molins, Joaquim, 1959-; Comperat, E.; De Santis, Maria; Huddart, R.; Loriot, Yohann; Necchi, Andrea; Valderrama, B.P.; Ravaud, A.; Shariat, S.F.; Szabados, B.; van der Heijden, M.S.; Gillessen, S.; ESMO Guidelines Committee (Elsevier, 2022)

Disclosure TP has received research funding from Merck Serono, Merck, Sharp & Dohme (MSD), Roche, Bristol Myers Squibb (BMS), AstraZeneca, Astellas, Novartis, Johnson and Johnson, Seattle Genetics, Pfizer, Exelixis and ...
Cancer-associated fibroblasts in bladder cancer: Origin, biology, and therapeutic opportunities

Caramelo, Belén; Zagorac, Sladjana; Corral, Sonia; Marqués, Miriam; Real, Francisco X. (Elsevier, 2023)

Context: Bladder cancer (BLCA) is a highly prevalent tumour and a health problem worldwide, especially among men. Recent work has highlighted the relevance of the tumour microenvironment (TME) in cancer biology with ...
Coffee consumption, genetic susceptibility and bladder cancer risk

Villanueva, Cristina M.; Silverman, Debra T.; Murta-Nascimento, Cristiane; Malats i Riera, Núria; García Closas, Montserrat; Castro Domínguez, Francisco; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Rothman, Nathaniel; Real, Francisco X.; Dosemeci, Mustafa; Kogevinas, Manolis (Springer, 2009)

Objective: We evaluated the bladder cancer risk associated with coffee consumption in a case–control study in Spain and examined the gene–environment interactions for genetic variants of caffeine-metabolizing enzymes. ...
ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

Powles, Thomas; Bellmunt Molins, Joaquim, 1959-; Mariathasan, Sanjeev (Nature Research, 2021)

Minimally invasive approaches to detect residual disease after surgery are needed to identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA (ctDNA) holds promise as a biomarker for ...
Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes

Koutros, Stella; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Silverman, Debra T. (Elsevier, 2020)

Background: The International Agency for Research on Cancer (IARC) classifies diesel engine exhaust as carcinogenic to humans based on sufficient evidence for lung cancer. IARC noted, however, an increased risk of bladder ...
E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing

Millán-Uclés, África; Zuluaga, Susana; Marqués, Marta; Vallejo-Díaz, Jesus; Sanz, Lorena; Cariaga-Martínez, Ariel E.; Real, Francisco X.; Carrera, Ana C. (Impact Journals, 2016)

Alterations in phosphatidylinositol 3-kinase (PI3K) and in PTEN (phosphatase and tensin homolog), the negative regulator of the PI3K pathway, are found in nearly half of human tumors. As PI3Kβ, the main isoform activated ...
Efficacy and safety of rucaparib in previously treated, locally advanced or metastatic urothelial carcinoma from a phase 2, open-label trial (ATLAS)

Grivas, Petros; Rodriguez-Vida, Alejo; Chowdhury, Simon (BioMed Central, 2021)

Background: ATLAS evaluated the efficacy and safety of the PARP inhibitor rucaparib in patients with previously treated locally advanced/unresectable or metastatic urothelial carcinoma (UC). Methods: Patients with UC were ...
Immunohistochemistry-based taxonomical classification of bladder cancer predicts response to neoadjuvant chemotherapy

Font, Albert; Doménech, Montserrat; Benítez, Raquel; Rava, Marta; Marqués, Miriam; Ramírez, José L.; Pineda, Silvia; Domínguez Rodríguez, Miriam; Gago, José L.; Badal, Josep; Carrato, Cristina; López, Héctor; Quer, Ariadna; Castellano, Daniel; Malats i Riera, Núria; Real, Francisco X. (MDPI, 2020)

Background: Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, patients with basal/squamous (BASQ)-like tumors ...
Immunotherapy in non-metastatic urothelial cancer: back to the 'future'

Darling, Harry S.; Bellmunt Molins, Joaquim, 1959- (Taylor & Francis, 2019)

INTRODUCTION: Successful results of immuno-oncological drugs in metastatic urothelial cancer have triggered the interest of researchers to test them in the non-metastatic setting. Conventional treatment modalities in that ...
LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk

Amaral, André F.S.; Tajuddin, Salman Muhammad; Fernández, Agustín F.; Chanock, Stephen J.; Silverman, Debra T.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Jackson, Brian P.; Toraño, Estela; Márquez, Miriam; González Urdinguio, Rocío; García Closas, Reina; Rothman, Nathaniel; Kogevinas, Manolis; Real, Francisco X.; Fernández Fraga, Mario; Malats i Riera, Núria (Cancer Research UK, 2014)

Background: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation ...
Mutations in non-tumoral human urothelium: disease prelude or epilogue?

Piedrafita, Gabriel; Fernández, Luis; Real, Francisco X. (IOS Press, 2020)

Bladder cancer is characterized by high rates of recurrence and multifocality, features which have commonly been associated with the colonization of widespread areas of non-neoplastic urothelium by mutant cells, a phenomenon ...
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses

García Closas, Montserrat; Malats i Riera, Núria; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Real, Francisco X.; Rothman, Nathaniel (Elsevier, 2005)

Background: Many reported associations between common genetic polymorphisms and complex diseases have not been confirmed in subsequent studies. An exception could be the association between NAT2 slow acetylation, GSTM1 ...
Polymorphisms in GSTT1, GSTZ1, AND CYP2E1, disinfection by-products, and risk of bladder cancer in Spain

Cantor, Kenneth P; Villanueva Belmonte, Cristina; Silverman, Debra T.; Figueroa, Jonine D.; Real, Francisco X.; García Closas, Montserrat; Malats i Riera, Núria; Chanock, Stephen J.; Yeager, Meredith; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Castaño Vinyals, Gemma; Samanic, Claudine; Rothman, Nathaniel; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2010)

Background: Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water.Objectives: In this study we investigated the combined influence of DBP exposure and polymorphisms in ...