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Visualitza Recerca: articles, congressos, llibres per matèria "Biologia computacional"

Visualitza Recerca: articles, congressos, llibres per matèria "Biologia computacional"

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  • Marchese, Domenica, 1986-; Livi, Carmen Maria; Tartaglia, Gian Gaetano (Humana Press (Springer Imprint), 2016)
    Protein–RNA interactions play important roles in a wide variety of cellular processes, ranging from transcriptional and posttranscriptional regulation of genes to host defense against pathogens. In this chapter we present ...
  • Steijger, Tamara; Guigó Serra, Roderic; RGASP Consortium (Nature Publishing Group, 2013)
    We evaluated 25 protocol variants of 14 independent computational methods for exon identification, transcript reconstruction and expression-level quantification from RNA-seq data. Our results show that most algorithms are ...
  • Guigó Serra, Roderic (Institut d'Estudis Catalans, 2000)
  • Torrent, Marc; Andreu Martínez, David; Nogués, Victòria M; Boix, Ester (Public Library of Science (PLoS), 2011)
    The increasing rate in antibiotic-resistant bacterial strains has become an imperative health issue. Thus, pharmaceutical industries have focussed their efforts to find new potent, non-toxic compounds to treat bacterial ...
  • Agirre Ortiz de Guzmán, Eneritz, 1983-; Eyras Jiménez, Eduardo (BioMed Central, 2011)
    Recent advances in high-throughput sequencing have facilitated the genome-wide studies of small non-coding RNAs (sRNAs). Numerous studies have highlighted the role of various classes of sRNAs at different levels of gene ...
  • Jiménez, Alba; Cotterell, James; Munteanu, Andreea; Sharpe, James (Cold Spring Harbor Laboratory Press, 2015)
    To what extent does the dynamical mechanism producing a specific biological phenotype bias the ability to evolve into novel phenotypes? We use the interpretation of a morphogen gradient into a single stripe of gene expression ...
  • Clark, Andrew; Prost, Stefan; Stanton, Jo-Ann L.; White, W. Timothy J.; Kaplan, Matthew E.; Matisoo Smith, Elizabeth; Genographic Consortium; Bertranpetit, Jaume, 1952-; Comas, David, 1969-; Haber, Marc, 1980-; Martínez Cruz, Begoña; Soria Hernanz, David F (BioMed Central, 2014)
    Background: Next-generation DNA sequencing (NGS) technologies have made huge impacts in many fields of biological research, but especially in evolutionary biology. One area where NGS has shown potential is for high-throughput ...
  • López Bigas, Núria; Pérez Llamas, Christian, 1976- (Public Library of Science (PLoS), 2011)
    Intuitive visualization of data and results is very important in genomics, especially when many conditions are to be analyzed and compared. Heat-maps have proven very useful for the representation of biological data. Here ...
  • Orobitg, Miquel; Guirado, Fernando; Cores, Fernando; Lladós, Jordi; Notredame, Cedric (Elsevier, 2015)
    Multiple Sequence Alignment (MSA) is essential for a wide range of applications in Bioinformatics. Traditionally, the alignment accuracy was the main metric used to evaluate the goodness of MSA tools. However, with the ...
  • Macía, Javier; Solé Vicente, Ricard, 1962- (Public Library of Science (PLoS), 2014)
    Biological systems perform computations at multiple scales and they do so in a robust way. Engineering metaphors have often been used in order to provide a rationale for modeling cellular and molecular computing networks ...
  • González-Pérez, Abel; López Bigas, Núria (Elsevier, 2011)
    Several large ongoing initiatives that profit from next-generation sequencing technologies have driven--and in coming years will continue to drive--the emergence of long catalogs of missense single-nucleotide variants ...
  • Martínez Jiménez, Francisco; Martí Renom, Marc A. (Public Library of Science (PLoS), 2015)
    Target identification is essential for drug design, drug-drug interaction prediction, dosage adjustment and side effect anticipation. Specifically, the knowledge of structural details is essential for understanding the ...
  • Deniz, Özgen; Flores, Oscar; Aldea, Martí; Soler López, Montserrat; Orozco, Modesto (Nature Publishing Group, 2016)
    Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational changes, however the ...
  • Digles, D.; Queralt Rosinach, Núria; Furlong, Laura I.; Jacoby, Edgar (Royal Society of Chemistry, 2016)
    Phenotypic screening is in a renaissance phase and is expected by many academic and industry leaders to accelerate the discovery of new drugs for new biology. Given that phenotypic screening is per definition target agnostic, ...
  • Sali, Andrej; Martí Renom, Marc A.; Westbrook, John D. (Elsevier, 2015)
    Structures of biomolecular systems are increasingly computed by integrative modeling that relies on varied types of experimental data and theoretical information. We describe here the proceedings and conclusions from the ...
  • Barardi, Alessandro; Sancristóbal, Belen; García Ojalvo, Jordi (Public Library of Science (PLoS), 2014)
    Synchronization between neuronal populations plays an important role in information transmission between brain areas. In particular, collective oscillations emerging from the synchronized activity of thousands of neurons ...
  • Althammer, Sonja Daniela; González-Vallinas Rostes, Juan, 1983-; Ballaré, Cecilia Julia; Beato, Miguel; Eyras Jiménez, Eduardo (Oxford University Press, 2011)
    MOTIVATION: High-throughput sequencing (HTS) has revolutionized gene regulation studies and is now fundamental for the detection of protein-DNA and protein-RNA binding, as well as for measuring RNA expression. With increasing ...
  • Lladós, Jordi; Guirado, Fernando; Cores, Fernando; Lérida, Josep Lluís; Notredame, Cedric (Springer, 2015)
    Multiple sequence alignment (MSA) is crucial for high-throughput next generation sequencing applications. Large-scale alignments with thousands of sequences are necessary for these applications. However, the quality of the ...
  • Plass Pórtulas, Mireya, 1982-; Codony Servat, Carles; Ferreira, Pedro G.; Vilardell, Josep; Eyras Jiménez, Eduardo (Cold Spring Harbor Laboratory Press (CSHL Press) -- RNA, 2012)
    Alternative splicing is the mechanism by which different combinations of exons in the pre-mRNA give rise to distinct mature mRNAs. This process is mediated by splicing factors that bind the pre-mRNA and affect the recognition ...