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Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

Barradas, Marta; Lázaro, Iolanda; Pozo Mendoza, Óscar J., 1975-; Sala Vila, Aleix; Fernandez-Marcos, Pablo J. (Nature Research, 2022)

Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, ...
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

Guerra, Carmen; Mijimolle, Nieves; Dhawahir, Alma; Dubus, Pierre; Barradas, Marta; Serrano, Manuel; Campuzano Uceda, María Victoria; Barbacid, Mariano (Elsevier, 2003)

We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires ...