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Browsing Recerca: articles, congressos, llibres by Subject "Immunotherapy"

Browsing Recerca: articles, congressos, llibres by Subject "Immunotherapy"

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  • Bellmunt Molins, Joaquim, 1959-; Powles, Thomas; Vogelzang, Nicholas J. (Elsevier, 2017)
    The treatment of bladder cancer has evolved over time to encompass not only the traditional modalities of chemotherapy and surgery, but has been particularly impacted by the use of immunotherapy. The first immunotherapy ...
  • Tauriello, Daniele V.F.; Calon, Alexandre; Lonardo, Enza; Batlle Gómez, Eduard (Wiley, 2017)
    Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early-stage ...
  • Martínez Pasamar, Sara; Abad Adan, Elena; Moreno, Beatriz; Vélez de Mendizábal, Nieves; Martínez Forero, Ivan; García Ojalvo, Jordi; Villoslada, Pablo (BioMed Central, 2013)
    Background: Multiple Sclerosis (MS) is considered a T-cell-mediated autoimmune disease with a prototypical oscillatory behavior, as evidenced by the presence of clinical relapses. Understanding the dynamics of immune cells ...
  • Martínez Bosch, Neus; Vinaixa, Judith; Navarro Medrano, Pilar (MDPI, 2018)
    Pancreatic ductal adenocarcinoma (PDA), the most frequent type of pancreatic cancer, remains one of the most challenging problems for the biomedical and clinical fields, with abysmal survival rates and poor therapy efficiency. ...
  • O’Meara, Tess; Safonov, Anton; Casadevall Aguilar, David; Qing, Tao; Silber, Andrea; Killelea, Brigid; Hatzis, Christos; Pusztai, Lajos (Springer, 2019)
    PURPOSE: African-American (AA) patients with triple-negative breast cancer (TNBC) are less likely to achieve pathologic complete response from neoadjuvant chemotherapy and have poorer prognosis than Caucasian patients with ...
  • Darling, Harry S.; Bellmunt Molins, Joaquim, 1959- (Taylor & Francis, 2019)
    INTRODUCTION: Successful results of immuno-oncological drugs in metastatic urothelial cancer have triggered the interest of researchers to test them in the non-metastatic setting. Conventional treatment modalities in that ...
  • Muntasell i Castellví, Aura, 1972-; Cabo, Mariona; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Martínez-García, Maria; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; López-Botet, Miguel (Frontiers, 2017)
    Overexpression of the human epidermal growth factor receptor 2 (HER2) defines a subgroup of breast tumors with aggressive behavior. The addition of HER2-targeted antibodies (i.e., trastuzumab, pertuzumab) to chemotherapy ...
  • Alvarez-Cienfuegos, Ana; Nuñez-Prado, Natalia; Compte, Marta; Cuesta, Angel M.; Blanco-Toribio, Ana; Harwood, Seandean Lykke; Villate, Maider; Merino, Nekane; Bonet Martínez, Jaume, 1982-; Navarro, Rocio; Muñoz-Briones, Clara; Sørensen, Karen Marie Juul; Mølgaard, Kasper; Oliva Miguel, Baldomero; Sanz, Laura; Blanco, Francisco; Alvarez-Vallina, Luis (Nature Publishing Group, 2016)
    Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to ...
  • Hardy-Werbin, Max; del Rey-Vergara, Raúl; Galindo-Campos, Miguel A.; Moliner Jiménez, Laura; Arriola Aperribay, Edurne (MDPI, 2019)
    Small cell lung cancer (SCLC) is the most aggressive type of lung cancer. The different systemic treatment approaches attempted in the last 35 years have not improved overall survival in the advanced stage. Targeted therapies ...
  • Rodriguez-Vida, Alejo (BMJ Publishing Group, 2017)
    During the last decade, the treatment of advanced or metastatic renal cell carcinoma (RCC) was revolutionised with the advent of antiangiogenic drugs and tyrosine-kinase inhibitors. Several agents targeting the vascular ...
  • Rodriguez-Vida, Alejo; Strijbos, Michiel; Hutson, Thomas Xavier (BMJ Publishing Group, 2017)
    In the past decade, several agents targeting angiogenesis and signal transduction pathways have replaced the use of cytokines as standard of care treatment for metastatic renal cell carcinoma (RCC) after showing improved ...
  • Salazar Degracia, Anna; Granado-Martínez, Paula; Millán-Sánchez, Aïna; Tang, Jun; Pons-Carreto, Alba; Barreiro Portela, Esther (Wiley, 2019)
    Identification of to what extent tumor burden influences muscle mass independently of specific treatments for cancer-cachexia remains to be elucidated. We hypothesized that reduced tumor burden by selective treatment of ...
  • Grimm, Marc-Oliver; Bex, Axel; De Santis, Maria; Ljunberg, Börje; Catto, James W.F.; Rouprêt, Morgan; Hussain, Syed; Bellmunt Molins, Joaquim, 1959-; Powles, Thomas; Wirth, Manfred; Van Poppel, Hendrik (Elsevier, 2019)
    Immune checkpoint inhibitors (ICIs) are now used routinely to treat advanced or metastatic urothelial and renal cell carcinoma, among other cancers. Furthermore, multiple trials are currently exploring their role in adjuvant, ...
  • Hardy-Werbin, Max; Rocha, Pedro P.; Arpí Llucià, Oriol; Taus García, Álvaro; Nonell Mazelón, Lara; Duran Jordà, Xavier, 1974-; Villanueva, Xavier; Joseph-Pietras, Deborah; Nolan, Luke; Danson, Sarah; Griffiths, Richard; López-Botet, M. (Miguel); Rovira Guerín, Ana; Albanell Mestres, Joan; Ottensmeier, Christian; Arriola Aperribay, Edurne (Taylor & Francis, 2019)
    Background. Immunotherapy has shown efficacy in small cell lung cancer (SCLC), but only a subset of patients benefits. Surrogate biomarkers are urgently needed. Our aim was to evaluate serum Th1, Th2, and proinflammatory ...
  • Pertsovskaya, Inna; Abad Adan, Elena; Domedel Puig, Núria; García Ojalvo, Jordi; Villoslada, Pablo (BioMed Central, 2013)
    Background: Interferon-beta (IFN-beta) activates the immune response through the type I IFN signaling pathway. IFN-beta is important in the response to pathogen infections and is used as a therapy for Multiple Sclerosis. ...

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