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Browsing Recerca: articles, congressos, llibres by Author "Zacco, Elsa"

Browsing Recerca: articles, congressos, llibres by Author "Zacco, Elsa"

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  • Probing TDP-43 condensation using an in silico designed aptamer
    Zacco, Elsa; Kantelberg, Owen; Milanetti, Edoardo; Armaos, Alexandros, 1989-; Panei, Francesco Paolo; Gregory, Jenna; Jeacock, Kiani; Clarke, David J.; Chandran, Siddharthan; Ruocco, Giancarlo; Gustincich, Stefano; Horrocks, Mathew H.; Pastore, Annalisa; Tartaglia, Gian Gaetano (Nature Research, 2022)
    Aptamers are artificial oligonucleotides binding to specific molecular targets. They have a promising role in therapeutics and diagnostics but are often difficult to design. Here, we exploited the catRAPID algorithm to ...
  • Probing TDP-43 condensation using an in silico designed aptamer
    Zacco, Elsa; Kantelberg, Owen; Milanetti, Edoardo; Armaos, Alexandros, 1989-; Panei, Francesco Paolo; Gregory, Jenna; Jeacock, Kiani; Clarke, David J.; Chandran, Siddharthan; Ruocco, Giancarlo; Gustincich, Stefano; Horrocks, Mathew H.; Pastore, Annalisa; Tartaglia, Gian Gaetano (Nature Research, 2022)
    Aptamers are artificial oligonucleotides binding to specific molecular targets. They have a promising role in therapeutics and diagnostics but are often difficult to design. Here, we exploited the catRAPID algorithm to ...
  • RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
    Zacco, Elsa; Graña-Montes, Ricardo; Martin, Stephen R.; Sanchez de Groot, Natalia; Alfano, Caterina; Tartaglia, Gian Gaetano; Pastore, Annalisa (Elsevier, 2019)
    Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) ...
  • RNA as the stone guest of protein aggregation
    Louka, Alexandra; Zacco, Elsa; Temussi, Piero Andrea; Tartaglia, Gian Gaetano; Pastore, Annalisa (Oxford University Press, 2020)
    The study of prions as infectious aggregates dates several decades. From its original formulation, the definition of a prion has progressively changed to the point that many aggregation-prone proteins are now considered ...
  • RNA-protein interactions: central players in coordination of regulatory networks
    Armaos, Alexandros, 1989-; Zacco, Elsa; Sanchez de Groot, Natalia; Tartaglia, Gian Gaetano (Wiley-VCH Verlag, 2021)
    Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the cell leading to toxicity and death. Here we exploit the information contained in protein, RNA and DNA interaction networks ...
  • Structural analysis of SARS-CoV-2 genome and predictions of the human interactome
    Vandelli, Andrea; Monti, Michele; Milanetti, Edoardo; Armaos, Alexandros, 1989-; Rupert, Jakob; Zacco, Elsa; Bechara, Elias; Delli Ponti, Riccardo, 1987-; Tartaglia, Gian Gaetano (Oxford University Press, 2020)
    Specific elements of viral genomes regulate interactions within host cells. Here, we calculated the secondary structure content of >2000 coronaviruses and computed >100 000 human protein interactions with severe acute ...
  • Zooming in on protein-RNA interactions: a multi-level workflow to identify interaction partners
    Colantoni, Alessio; Rupert, Jakob; Vandelli, Andrea; Tartaglia, Gian Gaetano; Zacco, Elsa (Portland Press, 2020)
    Interactions between proteins and RNA are at the base of numerous cellular regulatory and functional phenomena. The investigation of the biological relevance of non-coding RNAs has led to the identification of numerous ...

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