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In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis

Farrán, Aina; Valverde-Franco, Gladys; Tío, Laura; Lussier, Bertrand; Fahmi, Hassan; Pelletier, Jean-Pierre; Bishop, Paul N.; Monfort, Jordi; Martel-Pelletier, Johanne (Nature Research, 2018)

The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old ...