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  • Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors
    Elorza, Ainara; Márquez, Yamile; Cabrera, Jorge; Sánchez-Trincado, José Luis; Santos-Galindo, María; Hernández, Ivó H.; Picó, Sara; Díaz-Hernández, Juan I.; García-Escudero, Ramón; Irimia Martínez, Manuel; Lucas, José J. (Oxford University Press, 2021)
    Correction of mis-splicing events is a growing therapeutic approach for neurological diseases such as spinal muscular atrophy or neuronal ceroid lipofuscinosis 7, which are caused by splicing-affecting mutations. Non-mutation ...
  • Hybrid approach to model the spatial regulation of T cell responses
    Bouchnita, Anass; Bocharov, Gennady A.; Meyerhans, Andreas; Volpert, Vitaly (BioMed Central, 2017)
    BACKGROUND: Moving from the molecular and cellular level to a multi-scale systems understanding of immune responses requires the development of novel approaches to integrate knowledge and data from different biological ...
  • Hybrid intransitives in Basque
    Pineda, Anna; Berro, Ane (Ubiquity Press, 2020)
    This paper deals with a group of agentive verbs in Eastern dialects of Basque that show mixed unergative and unaccusative properties. Although they pattern with unergatives in certain aspects, they combine with an absolutive ...
  • Hybridization and emergence of virulence in opportunistic human yeast pathogens
    Mixão, Verónica; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2018)
    Hybridization between different species can result in the emergence of new lineages and adaptive phenotypes. Occasionally, hybridization in fungal organisms can drive the appearance of opportunistic lifestyles or shifts ...
  • Hydrophilic or lipophilic statins?
    Climent Biescas, Elisenda; Benaiges Foix, David; Pedro-Botet, Juan Carlos (Frontiers, 2021)
    Drugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in water or in lipid-containing media. The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin ...
  • Hydrotalcite-embedded magnetite nanoparticles for hyperthermia-triggered chemotherapy
    Simeonidis, Konstantinos; Kaprara, Efthimia; Rivera Gil, Pilar, 1976-; Xu, Ruixue; Teran, Francisco J.; Kokkinos, Evgenios; Mitropoulos, Athanassios; Maniotis, Nikolaos; Balcells, Lluis (MDPI, 2021)
    A magnetic nanocomposite, consisting of Fe3O4 nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia ...
  • HypercubeME: two hundred million combinatorially complete datasets from a single experiment
    Esteban, Laura Avino; Lonishin, Lyubov R.; Bobrovskiy, Daniil; Leleytner, Gregory; Bogatyreva, Natalya S.; Kondrashov, Fyodor A., 1979-; Ivankov, Dmitry N. (Oxford University Press, 2020)
    Motivation: Epistasis, the context-dependence of the contribution of an amino acid substitution to fitness, is common in evolution. To detect epistasis, fitness must be measured for at least four genotypes: the reference ...
  • Hyperinsulinemic Hypoglycemia after Bariatric Surgery: Diagnosis and Management Experience from a Spanish Multicenter Registry.
    Vilarrasa, Nuria; Goday Arno, Alberto; Rubio Pérez, Miguel Angel; Caixàs, Assumpta; Pellitero, Silvia; Ciudin, Andrea; Calañas, Alfonso; Botella, José Ignacio; Bretón, Irene; Morales, María José; Díaz-Fernández, María Jesús; García-Luna, Pedro Pablo; Lecube, Albert (Karger, 2016)
    BACKGROUND: Severe postprandial hypoglycemia after bariatric surgery is a rare but invalidating complication. Our aim was to describe the different tests performed for its diagnosis and their outcomes as well as the response ...
  • Hypermetabolic bone on 18 F-FDG-PET/CT in a patient with lung cancer: is it always metastasis?
    Martín-Ontiyuelo, Clara; Sánchez Font, Albert; Gimeno Vázquez, Eva; Suárez-Piñera, Marina; Curull Serrano, Víctor (Elsevier, 2020)
  • Hypernym extraction: combining machine-learning and dependency grammar
    Espinosa-Anke, Luis; Ronzano, Francesco; Saggion, Horacio (Springer, 2015)
    Hypernym extraction is a crucial task for semantically motivated NLP tasks such as taxonomy and ontology learning, textual entailment or paraphrase identification. In this paper, we describe an approach to hypernym extraction ...
  • Hyperparameter-tuned prediction of somatic symptom disorder using functional near-infrared spectroscopy-based dynamic functional connectivity
    Eken, Aykut; Çolak, Burçin; Bal, Neşe Burcu; Kuşman, Adnan; Kızılpınar, Selma Çilem; Akasla, Damla Sayar; Baskak, Bora (IOP Publishing Ltd., 2019)
    Objective. Somatic symptom disorder (SSD) is a reflection of medically unexplained physical symptoms that lead to distress and impairment in social and occupational functioning. SSD is phenomenologically diagnosed and its ...
  • Hypersensitivity or hyperreactivity? an experimental investigation in borderline personality disorder
    Bortolla, Roberta; Cavicchioli, Marco; Soler, Joaquim; Pascual, Juan C.; Verschure, Paul F. M. J.; Maffei, Cesare (University of Messina, 2020)
    Objective: Starting from the controversial results showed by empirical research on Linehan’s Biosocial model of Borderline Personality Disorder (BPD), this study aims to empirically evaluate Linehan’s conceptualization of ...
  • Hypersensitivity reaction caused by folinic acid administration: a case report and literature review.
    Florit-Sureda, Marta; Conde Estévez, David; Vidal Barrull, Joana; Montagut Viladot, Clara (Maney Publishing, 2016)
    5-Fluorouracil (5-FU) is combined with folinic acid (FA) for enhancing its cytotoxic effects in the colon cancer chemotherapy treatment. Folinic acid has rarely been involved in hypersensitivity reactions. Here, we report ...
  • Hyperspectral image processing for the identification and quantification of lentiviral particles in fluid samples
    Gomez‑Gonzalez, Emilio; Fernandez‑Muñoz, Beatriz; Barriga‑Rivera, Alejandro; Navas‑Garcia, Jose Manuel; Fernandez‑Lizaranzu, Isabel; Muñoz‑Gonzalez, Francisco Javier; Parrilla‑Giraldez, Ruben; Requena‑Lancharro, Desiree; Guerrero‑Claro, Manuel; Gil‑Gamboa, Pedro; Rosell‑Valle, Cristina; Gomez‑Gonzalez, Carmen; Mayorga‑Buiza, Maria Jose; Martin‑Lopez, Maria; Muñoz, Olga; Gomez Martin, Juan Carlos; Relimpio Lopez, Maria Isabel; Aceituno‑Castro, Jesus; Perales‑Esteve, Manuel A.; Puppo‑Moreno, Antonio; Gómez Gutiérrez, Emilia, 1975-; Sanchez Pernaute, Rosario; Padillo‑Ruiz, Javier; Marquez‑Rivas, Javier (Nature Research, 2021)
    Optical spectroscopic techniques have been commonly used to detect the presence of biofilm-forming pathogens (bacteria and fungi) in the agro-food industry. Recently, near-infrared (NIR) spectroscopy revealed that it is ...
  • Hyperspectral-enhanced dark field analysis of individual and collective photo-responsive gold-copper sulfide nanoparticles
    Zamora Pérez, Paula, 1988-; Pelaz, Beatriz; Tsoutsi, Dionysia; Soliman, Mahmoud G.; Parak, Wolfgang J.; Rivera Gil, Pilar, 1976- (Royal Society of Chemistry, 2021)
    We used hyperspectral-enhanced dark field microscopy for studying physicochemical changes in biomaterials by tracking their unique spectral signatures along their pathway through different biological environments typically ...
  • Hyperspectral-enhanced dark field microscopy for single and collective nanoparticle characterization in biological environments
    Zamora-Perez, Paula; Tsoutsi, Dionysia; Xu, Ruixue; Rivera Gil, Pilar, 1976- (MDPI, 2018)
    We review how the hyperspectral dark field analysis gives us quantitative insights into the manner that different nanoscale materials interact with their environment and how this relationship is directly expressed in an ...
  • Hypertensive mediated organ damage evolution in resistant hypertension patients after adding spironolactone
    Galceran Herrera, Isabel; Vázquez, Susana; Crespo Barrio, Marta; Pascual Santos, Julio; Oliveras, Anna (Elsevier, 2023)
    Introduction: Resistant hypertension (RH) represents an important multi-organic impact and increases the morbi-mortality. We aimed to evaluate the evolution of hypertensive mediated organ damage in patients with RH after ...
  • Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal
    Plaza-Zabala, Ainhoa, 1982-; Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2012)
    BACKGROUND: Hypocretin (orexin) signaling is involved in drug addiction. In this study, we investigated the role of these hypothalamic neuropeptides in nicotine withdrawal by using behavioral and neuroanatomical approaches. ...
  • Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior
    Plaza-Zabala, Ainhoa, 1982-; Martín García, Elena, 1975-; Lecea, Luis de; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Society for Neuroscience, 2010)
    Emerging evidence suggests that the hypocretinergic system is involved in addictive behavior. In this study, we investigated the role of these hypothalamic neuropeptides in anxiety-like responses of nicotine and stress-induced ...
  • Hypofractionated boost after whole breast irradiation in breast carcinoma: chronic toxicity results and cosmesis
    Sanz Latiesas, Javier, 1967-; Rodríguez, Nuria; Foro Arnalot, Palmira; Dengra, Josefa; Reig, Anna; Pérez, Paula; Membrive, Ismael; Ortiz, Ana; Codinach, Maria; Algara López, Manuel-Ignacio (Springer, 2017)
    PURPOSE: To evaluate the impact of hypofractionated boost after hypofractionated whole breast irradiation in breast carcinoma. METHODS AND MATERIALS: Patients after breast conservative surgery were treated all time with ...

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