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  • A dynamical systems hypothesis of schizophrenia
    Loh, Marco; Rolls, Edmund T; Deco, Gustavo (Public Library of Science (PLoS), 2007)
    We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity ...
  • A European benchmarking system to evaluate in-hospital mortality rates in acute coronary syndrome: The EURHOBOP project.
    Dégano, Irene R.; Subirana Cachinero, Isaac; Torre, Marina; Grau Magaña, Maria; Vila, Joan; Fusco, Danilo; Kirchberger, Inge; Ferrières, Jean; Malmivaara, Antti; Azevedo, Ana; Meisinger, Christa; Bongard, Vanina; Farmakis, Dimitrios; Davoli, Marina; Häkkinen, Unto; Araújo, Carla; Lekakis, John; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume (Elsevier, 2015)
    BACKGROUND: Hospital performance models in acute myocardial infarction (AMI) are useful to assess patient management. While models are available for individual countries, mainly US, cross-European performance models are ...
  • A faecal microbiota signature with high specificity for pancreatic cancer
    Kartal, Ece; Real, Francisco X.; Bork, Peer (BMJ Publishing Group, 2022)
    Background: recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. Objective: to explore the faecal and salivary microbiota as potential diagnostic biomarkers. ...
  • A family carrying a homozygous LACC1 truncated mutation expands the clinical phenotype of this disease beyond systemic-onset juvenile idiopathic arthritis
    Aróstegui Gorospe, Juan Ignacio; Rabionet, Raquel; Remesal, Agustín; Mensa Vilaró, Anna; Murias, Sara; Alcobendas, Rosa; González-Roca, Eva; Dreschsel, Oliver; Ruíz Ortiz, Estíbaliz; Puig, Anna; Comas, David, 1969-; Ossowski, Stephan; Yagüe, Jordi L.; Estivill, Xavier, 1955-; Merino, Rosa (BioMed Central, 2015)
    We identified a consanguineous Moroccan family with three affected siblings diagnosed with rheumatoid factor-negative polyarticular juvenile idiopathic arthritis. They all suffered from an early-onset (2-4 years-old) chronic ...
  • A fast non-parametric test of association for multiple traits
    Garrido Martín, Diego, 1992-; Calvo, Miquel (Calvo Llorca); Reverter, Ferran; Guigó Serra, Roderic (BioMed Central, 2023)
    The increasing availability of multidimensional phenotypic data in large cohorts of genotyped individuals requires efficient methods to identify genetic effects on multiple traits. Permutational multivariate analysis of ...
  • A feasibility study of patients with major depression and substance use disorders: vortioxetine as maintenance treatment
    Basurte-Villamor, Ignacio; Vega, Pablo; Roncero, Carlos; Martínez Raga, Jose; Grau-López, Lara; Aguilar, Lourdes; Torrens, Marta; Szerman, Nestor (Dove Medical Press, 2022)
    Background: limited studies have evaluated the effectiveness of vortioxetine in real-world settings, and none of them has involved patients with dual depression (major depressive disorder [MDD] and substance use disorder ...
  • A field guide for the compositional analysis of any-omics data
    Quinn, Thomas P.; Erb, Ionas; Gloor, Greg; Notredame, Cedric; Richardson, Mark F.; Crowley, Tamsyn M. (Oxford University Press, 2019)
    Background: Next-generation sequencing (NGS) has made it possible to determine the sequence and relative abundance of all nucleotides in a biological or environmental sample. A cornerstone of NGS is the quantification of ...
  • A fine-grained analysis of the acoustic cues involved in verbal irony recognition in French
    González Fuente, Santiago; Prieto Vives, Pilar, 1965-; Noveck, Ira A. (International Speech Communication Association, 2016)
    Research on verbal irony has found that prosodic features such as pitch range expansion, syllable lengthening, and specific intonational contours are common prosodic resources that languages use to mark irony in speech. ...
  • A finer-grained linguistic profile of Alzheimer’s disease and Mild Cognitive Impairment
    Chapin, Kayla B.; Clarke, Natasha; Garrard, Peter; Hinzen, Wolfram (Elsevier, 2022)
    Linguistic measures in spontaneous speech have shown promise in the early detection of Alzheimer’s disease (AD), but it remains unknown which specific linguistic variables show sensitivity and how language decline relates ...
  • A first approach to the automatic detection of zero subjects and impersonal constructions in portuguese
    Rello, Luz, 1984-; Ferraro, Gabriela; Gayo, Iria (Sociedad Española para el Procesamiento del Lenguaje Natural (SEPLN), 2012)
    Este trabajo constituye un primer intento de abordar la detección automática de sujetos elididos y de construcciones impersonales en portugués de Brasil, una tarea que no nos consta que se haya llevado a cabo previamente ...
  • A Fluctuation-driven mechanism for slow decision processes in reverberant networks
    Martí, Daniel; Deco, Gustavo; Mattia, Maurizio; Gigante, Guido; Del Giudice, Paolo (Public Library of Science (PLoS), 2008)
    The spike activity of cells in some cortical areas has been found to be correlated with reaction times and behavioral responses during two-choice decision tasks. These experimental findings have motivated the study of ...
  • A foreign body reaction to Surgicel® in a lymph node diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration
    Badenes Bonet, Diana, 1987-; Pijuan Andujar, Lara; Curull Serrano, Víctor; Sánchez-Font, Albert (Medknow Publications, 2017)
    Surgicel® (Ethicon, North Ryde, NSW, Australia) is an absorbable sheet of oxidized cellulose polyanhydroglucuronic acid polymer used as an hemostatic in cardiovascular and thoracic surgery. In some cases, the retained ...
  • A forensic population database in El Salvador: 58 STRs and 94 SNPs
    Casals López, Ferran; Rasal Soteras, Raquel; Anglada Busquets, Roger; Tormo, Marc; Bonet, Núria; Rivas, Nury; Vásquez, Patricia; Calafell i Majó, Francesc (Elsevier, 2021)
    We have genotyped the 58 STRs (27 autosomal, 24 Y-STRs and 7 X-STRs) and 94 autosomal SNPs in Illumina ForenSeq™ Primer Mix A in a sample of 248 men and 143 women from El Salvador, Central America. Regional division (Centro, ...
  • A Framework for multi-f0 modeling in SATB choir recordings
    Cuesta, Helena; Gómez Gutiérrez, Emilia, 1975-; Chandna, Pritish (Sound and Music Computing, 2019)
    Fundamental frequency (f0) modeling is an important but relatively unexplored aspect of choir singing. Performance evaluation as well as auditory analysis of singing, whether individually or in a choir, often depend on ...
  • A framework for semantic text clustering
    Usuari de càrrega; EL Saili, Chama; Alaoui, Larbi (SAI Organization, 2020)
    Existing approaches for text clustering are either agglomerative, divisive or based on frequent itemsets. However, most of the suggested solutions do not take the semantic associations between words into account and ...
  • A full competing risk analysis of hospital-acquired infections can easily be performed by a case-cohort approach
    Wolkewitz, M.; Palomar Martínez, Mercedes; Olaechea-Astigarraga, P.; Álvarez Lerma, Francisco; Schumacher, Martin (Elsevier, 2016)
    OBJECTIVES: We provide a case-cohort approach and show that a full competing risk analysis is feasible even in a reduced data set. Competing events for hospital-acquired infections are death or discharge from the hospital ...
  • A Full-body interactive videogame used as a tool to foster social initiation conducts in children with Autism Spectrum Disorders
    Parés, Narcís, 1966-; Mairena, Maria Angeles; Mora Guiard, Joan; Malinverni, Laura; Padillo, Vanesa; Valero, Lilia; Hervás, Amaia; Parés, Narcís, 1966- (Elsevier, 2019)
    Background Game-based interventions that involve the use of technology have shown to facilitate motivation and learning processes in children with Autism Spectrum Disorders (ASD). The purpose of this observational study ...
  • A fully integrated machine learning scan of selection in the chimpanzee genome
    Nye, Jessica, 1986-; Mondal, Mayukh, 1989-; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Oxford University Press, 2020)
    After diverging, each chimpanzee subspecies has been the target of unique selective pressures. Here, we employ a machine learning approach to classify regions as under positive selection or neutrality genome-wide. The ...
  • A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave
    Gaspa, Laura; González Medina, Alberto, 1990-; Hidalgo Hernando, Elena; Ayté del Olmo, José (Taylor & Francis (Routledge), 2016)
    The Schizosaccharomyces pombe MBF complex activates the transcription of genes required for DNA synthesis and S phase. The MBF complex contains several proteins, including the core components Cdc10, Res1 and Res2, the ...
  • A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma
    Chinnaswamy, Sreedhar; Wardzynska, Aleksandra; Pawelczyk, Malgorzata; Makowska, Joanna; Skaaby, Tea; Mercader Bigas, Josep Maria; Ahluwalia, Tarunveer Singh; Grarup, Niels; Guindo Martínez, Marta; Bisgaard, Hans; Torrents, David; Linneberg, Allan; Bønnelykke, Klaus; Kowalski, Marek L. (Nature Publishing Group, 2017)
    Lambda interferons (IFNLs) have immunomodulatory functions at epithelial barrier surfaces. IFN-λ4, a recent member of this family is expressed only in a subset of the population due to a frameshift-causing DNA polymorphism ...

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