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Presence of blastocystis in gut microbiota is associated with cognitive traits and decreased executive function

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dc.contributor.author Mayneris Perxachs, Jordi
dc.contributor.author Arnoriaga Rodríguez, María
dc.contributor.author Garre-Olmo, Josep
dc.contributor.author Puig, Josep
dc.contributor.author Ramos, Rafel
dc.contributor.author Trelis, Maria
dc.contributor.author Burokas, Aurelijus
dc.contributor.author Coll, Clàudia
dc.contributor.author Zapata-Tona, Cristina
dc.contributor.author Pedraza, Salvador
dc.contributor.author Pérez Brocal, Vicente
dc.contributor.author Ramió-Torrentà, Lluís
dc.contributor.author Ricart, Wifredo
dc.contributor.author Moya, Andrés
dc.contributor.author Jové, Mariona
dc.contributor.author Sol, Joaquim
dc.contributor.author Portero Otín, Manuel
dc.contributor.author Pamplona, Reinald
dc.contributor.author Maldonado, Rafael, 1961-
dc.contributor.author Fernández Real, Jose M.
dc.date.accessioned 2022-11-10T08:11:05Z
dc.date.available 2022-11-10T08:11:05Z
dc.date.issued 2022
dc.identifier.citation Mayneris-Perxachs J, Arnoriaga-Rodríguez M, Garre-Olmo J, Puig J, Ramos R, Trelis M, et al. Presence of blastocystis in gut microbiota is associated with cognitive traits and decreased executive function. ISME J. 2022 Sep; 16(9): 2181-97. DOI: 10.1038/s41396-022-01262-3.
dc.identifier.issn 1751-7362
dc.identifier.uri http://hdl.handle.net/10230/54786
dc.description.abstract Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery (n = 114) and replication cohorts (n = 942). We also found that Blastocystis was linked to bacterial functions related to aromatic amino acids metabolism and folate-mediated pyrimidine and one-carbon metabolism. Blastocystis-associated shifts in bacterial functionality translated into the circulating metabolome. Finally, we evaluated the effects of microbiota transplantation. Donor's Blastocystis subtypes led to altered recipient's mice cognitive function and prefrontal cortex gene expression. In summary, Blastocystis warrant further consideration as a novel actor in the gut microbiome-brain axis.
dc.description.sponsorship This study was partially funded by the Catalan Government (AGAUR, #SGR2017-0734, ICREA Academia Award 2021) to J.M.F.-R., Instituto de Salud Carlos III (Madrid, Spain) through the projects PI15/01934, PI18/01022 and PI21/01361 to JMF-R, the project PI20/01090 (Co-funded by European Regional Development Fund “A way to make Europe”) to JM-P, and the project PI20/0155 to MP-O; the grants SAF2015-65878-R from Ministry of Economy and Competitiveness, Prometeo/2018/A/133 from Generalitat Valenciana, Spain and also by Fondo Europeo de Desarrollo Regional (FEDER) funds (“A way to build Europe”), European Commission (FP7), the Catalan Government (AGAUR, #SGR2017-669, ICREA Academia Award 2020 and Ministerio de Ciencia e Innovación PID2020- 120029GB-I00/MICIN/AEI/10.13039/501100011033, and RD21/0009/0019, European Commission-DG Research” (PainFact, H2020-SC1-2019-2-RTD-848099, QSPain Relief, H2020-SC1-2019-2-RTD-848068 to R.M.), the Spanish Instituto de Salud Carlos III (RTA, #RD16/0017/0020) and the European Regional Development Fund (project No. 01.2.2-LMT-K-718-02-0014) under grant agreement with the Research Council of Lithuania (LMTLT). We also acknowledge funding from the Spanish Ministry of Science, Innovation and Universities (RTI2018-099200-B-I00), and the Generalitat of Catalonia (Agency for Management of University and Research Grants (2017SGR696) and Department of Health (SLT002/16/00250)) to RP; María Arnoriaga-Rodríguez is funded by Instituto de Salud Carlos III, Río Hortega (CM19/00190). JM-P is funded by Instituto de Salud Carlos III through the Miguel Servet Program project CP18/00009 (Co-funded by the European Social Fund “Investing in your future”). MJ is a “Serra-Hunter” fellow.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.
dc.rights.uri http://creativecommons. org/licenses/by/4.0/
dc.subject.other Blastocist -- Infecció
dc.subject.other Microbioma
dc.subject.other Cognició
dc.title Presence of blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41396-022-01262-3
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848099
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2015-65878-R
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848068
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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