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4D reconstruction of murine developmental trajectories using spherical harmonics

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dc.contributor.author Dalmasso, Giovanni
dc.contributor.author Musy, Marco
dc.contributor.author Niksic, Martina
dc.contributor.author Robert Moreno, Alexandre
dc.contributor.author Badía Careaga, Claudio
dc.contributor.author Sanz-Ezquerro, Juan José
dc.contributor.author Sharpe, James
dc.date.accessioned 2022-10-26T06:25:37Z
dc.date.available 2022-10-26T06:25:37Z
dc.date.issued 2022
dc.identifier.citation Dalmasso G, Musy M, Niksic M, Robert-Moreno A, Badía-Careaga C, Sanz-Ezquerro JJ, Sharpe J. 4D reconstruction of murine developmental trajectories using spherical harmonics. Dev Cell. 2022 Sep 12;57(17):2140-50.e5. DOI: 10.1016/j.devcel.2022.08.005
dc.identifier.issn 1534-5807
dc.identifier.uri http://hdl.handle.net/10230/54591
dc.description.abstract Normal organogenesis cannot be recapitulated in vitro for mammalian organs, unlike in species including Drosophila and zebrafish. Available 3D data in the form of ex vivo images only provide discrete snapshots of the development of an organ morphology. Here, we propose a computer-based approach to recreate its continuous evolution in time and space from a set of 3D volumetric images. Our method is based on the remapping of shape data into the space of the coefficients of a spherical harmonics expansion where a smooth interpolation over time is simpler. We tested our approach on mouse limb buds and embryonic hearts. A key advantage of this method is that the resulting 4D trajectory can take advantage of all the available data while also being able to interpolate well through time intervals for which there are little or no data. This allows for a quantitative, data-driven 4D description of mouse limb morphogenesis.
dc.description.sponsorship This research was supported by core funding from EMBL and CRG, and also the ERC advanced grant SIMBIONT (project no. 670555) and a grant from the Fundacion La Marato TV3 (grant 082030). G.D. and M.M. were supported by the ERC advanced grant SIMBIONT (project no. 670555).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Dev Cell. 2022 Sep 12;57(17):2140-50.e5
dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title 4D reconstruction of murine developmental trajectories using spherical harmonics
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.devcel.2022.08.005
dc.subject.keyword OPT
dc.subject.keyword Heart growth
dc.subject.keyword Limb growth
dc.subject.keyword Morphogenesis
dc.subject.keyword Mouse development
dc.subject.keyword Spherical harmonics
dc.subject.keyword Voxel data
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/670555
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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