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Cumulative risk of a false-positive screening result: a retrospective cohort study using empirical data from 10 biennial screening rounds in BreastScreen Norway

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dc.contributor.author Tsuruda, Kaitlyn M.
dc.contributor.author Larsen, Marthe
dc.contributor.author Román, Marta
dc.contributor.author Hofvind, Solveig
dc.date.accessioned 2022-09-29T06:50:47Z
dc.date.available 2022-09-29T06:50:47Z
dc.date.issued 2022
dc.identifier.citation Tsuruda KM, Larsen M, Román M, Hofvind S. Cumulative risk of a false-positive screening result: a retrospective cohort study using empirical data from 10 biennial screening rounds in BreastScreen Norway. Cancer. 2022 Apr 1; 128(7): 1373-80. DOI: 10.1002/cncr.34078.
dc.identifier.issn 0008-543X
dc.identifier.uri http://hdl.handle.net/10230/54202
dc.description.abstract Background: false-positive screening results are an inevitable and commonly recognized disadvantage of mammographic screening. This study estimated the cumulative probability of experiencing a first false-positive screening result in women attending 10 biennial screening rounds in BreastScreen Norway, which targets women aged 50 to 69 years. Methods: this retrospective cohort study analyzed screening outcomes from 421,545 women who underwent 1,894,523 screening examinations during 1995-2019. Empirical data were used to calculate the cumulative risk of experiencing a first false-positive screening result and a first false-positive screening result that involved an invasive procedure over 10 screening rounds. Logistic regression was used to evaluate the effect of adjusting for irregular attendance, age at screening, and number of screens attended. Results: the cumulative risk of experiencing a first false-positive screening result was 18.04% (95% confidence interval [CI], 18.00%-18.07%). It was 5.01% (95% CI, 5.01%-5.02%) for experiencing a false-positive screening result that involved an invasive procedure. Adjusting for irregular attendance or age at screening did not appreciably affect these estimates. After adjustments for the number of screens attended, the cumulative risk of a first false-positive screening result was 18.28% (95% CI, 18.24%-18.32%), and the risk of a false-positive screening result including an invasive procedure was 5.11% (95% CI, 5.11%-5.22%). This suggested that there was minimal bias from dependent censoring. Conclusions: nearly 1 in 5 women will experience a false-positive screening result if they attend 10 biennial screening rounds in BreastScreen Norway. One in 20 will experience a false-positive screening result with an invasive procedure. lay summary: A false-positive screening result occurs when a woman attending mammographic screening is called back for further assessment because of suspicious findings, but the assessment does not detect breast cancer. Further assessment includes additional imaging. Usually, it involves ultrasound, and sometimes, it involves a biopsy. This study has evaluated the chance of experiencing a false-positive screening result among women attending 10 screening examinations over 20 years in BreastScreen Norway. Nearly 1 in 5 women will experience a false-positive screening result over 10 screening rounds. One in 20 women will experience a false-positive screening result involving a biopsy.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights © 2021 Tsuruda KM, Larsen M, Román M, Hofvind S. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License http://creativecommons.org/licenses/by-nc/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Cumulative risk of a false-positive screening result: a retrospective cohort study using empirical data from 10 biennial screening rounds in BreastScreen Norway
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/cncr.34078
dc.subject.keyword Breast neoplasms
dc.subject.keyword False-positive reactions
dc.subject.keyword Mammography
dc.subject.keyword Mass screening
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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